Evidence map›Paper›PMID 38510207›Full record

ArticleStem cells international2024

Stimulated Human Umbilical Cord Mesenchymal Stem Cells Enhance the Osteogenesis and Cranial Bone Regeneration through IL-32 Mediated P38 Signaling Pathway.

Xiaru Zhang, Ying Zheng, Gang Wang, Yuanlin Liu, Yang Wang, Xueyi Jiang, Yueqing Liang, Xinfeng Zhao, Ping Li, Yi Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Xiaru ZhangDepartment of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100085, China.ORCID https://orcid.org/0000-0001-6114-5463
Ying ZhengDepartment of Stomatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.ORCID https://orcid.org/0000-0002-5113-5330
Gang WangMedical School of Chinese PLA, Beijing 100853, China.ORCID https://orcid.org/0009-0008-1018-7645
Yuanlin LiuDepartment of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100085, China.ORCID https://orcid.org/0000-0001-9614-2908
Yang WangDepartment of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100085, China.ORCID https://orcid.org/0000-0003-3126-3367
Xueyi JiangLaboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children's Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing 100045, China.ORCID https://orcid.org/0009-0006-8714-4606
Yueqing LiangLaboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children's Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing 100045, China.ORCID https://orcid.org/0009-0001-9593-2817
Xinfeng ZhaoDepartment of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100085, China.ORCID https://orcid.org/0009-0002-5242-7025
Ping LiLaboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children's Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing 100045, China.ORCID https://orcid.org/0000-0002-1310-1092
Yi ZhangDepartment of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100085, China.ORCID https://orcid.org/0000-0003-2498-3948
Center for Children · USCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Our previous study found that it could significantly increase the expression of IL32 after stimulating the human umbilical cord mesenchymal stem cells (S-HuMSCs). However, its role on the osteogenesis and cranial bone regeneration is still largely unknown. Here, we investigated the possible mechanism of this effect. Results: In total, it found that compared to HuMSCs, IL32 was significantly increased and promoted the osteogenic differentiation (lower expressions of PPAR Conclusion: We have confirmed that S-HuMSCs can enhance the osteogenesis and cranial bone regeneration through promoting IL-32-mediated P38 signaling pathway, which is proved that IL-32 may be a therapeutic target, or a biomarker for the treatment of cranial bone injuries.

Identifiers

PMID38510207
PMCPMC10954361
OpenAlexW4392744700

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.