Evidence map›Paper›PMID 38509951›Full record

ArticleHeliyon2024

Mechanism of Bazi Bushen capsule in delaying the senescence of mesenchymal stem cells based on network pharmacology and experimental validation.

Yaping Zhang, Tongxing Wang, Yanfei Song, Meng Chen, Bin Hou, Bing Yao, Kun Ma, Yahui Song, Siwei Wang, Dan Zhang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yaping ZhangGraduate School, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China.
Tongxing WangNational Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China.
Yanfei SongNational Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China.
Meng ChenNational Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China.
Bin HouNational Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China.
Bing YaoNational Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China.
Kun MaNational Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China.
Yahui SongNational Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China.
Siwei WangGraduate School, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China.
Dan ZhangGraduate School, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China.
Junqing LiangNational Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China.
Cong WeiGraduate School, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China.
State Administration of Traditional Chinese Medicine of the People's Republic of China · CNHebei University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ageing is becoming an increasingly serious problem; therefore, there is an urgent need to find safe and effective anti-ageing drugs. Aims: To investigate the effects of Bazi Bushen capsule (BZBS) on the senescence of mesenchymal stem cells (MSCs) and explore its mechanism of action. Methods: Network pharmacology was used to predict the targets of BZBS in delaying senescence in MSCs. For Results: Network pharmacological analysis suggested that BZBS delayed cell senescence by interfering in the cell cycle. Our Conclusions: BZBS can protect MSCs against D-gal-induced senescence, which may be associated with cell cycle regulation via the Cyclin D1/CDK4/E2F1 signalling pathway.

Indexed as

Bazi bushen capsuleCell cycleCell senescenceMesenchymal stem cellsNetwork pharmacology

Identifiers

PMID38509951
PMCPMC10950659
OpenAlexW4392630733

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.