Evidence map›Paper›PMID 38509850›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Robotic Actuation-Mediated Quantitative Mechanogenetics for Noninvasive and On-Demand Cancer Therapy.

Yangyi Liu, Jingjing Li, Yi Zhang, Fan Wang, Juanjuan Su, Chao Ma, Shuyi Zhang, Yanan Du, Chunhai Fan, Hongjie Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Traceless Regulation of Genetic Circuitry.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yangyi LiuCenter of Materials Science and Optoelectronics Engineering, College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.ORCID 0000-0003-0756-2498
Jingjing LiState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.ORCID 0000-0002-7526-5308
Yi ZhangEngineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.
Fan WangState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Juanjuan SuCenter of Materials Science and Optoelectronics Engineering, College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.
Chao MaEngineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.
Shuyi ZhangSchool of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
Yanan DuDepartment of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
Chunhai FanXiangfu Laboratory, Jiaxing, 314102, China.
Hongjie ZhangEngineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.
Kai LiuEngineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.ORCID 0000-0003-0878-5191

Funding

Beijing Nova Program Z211100002121132Key Technologies Research and Development Program 2018YFA0902600Key Technologies Research and Development Program 2020YFA0908900Key Technologies Research and Development Program 2021YFF1200300Key Technologies Research and Development Program 2022YFA0913200Key Technologies Research and Development Program 2022YFF0710000National Natural Science Foundation of China 22020102003National Natural Science Foundation of China 22107097National Natural Science Foundation of China 22125701National Natural Science Foundation of China 22277064National Natural Science Foundation of China 22377121National Natural Science Foundation of China 22388101National Natural Science Foundation of China 82272161National Natural Science Foundation of China T2322025Natural Science Foundation of Beijing Municipality 2222010Xiangfu Lab Research Project XF012022C0200Youth Innovation Promotion Association of the Chinese Academy of Sciences 2021226
6 · The paper itself

Abstract

Cell mechanotransduction signals are important targets for physical therapy. However, current physiotherapy heavily relies on ultrasound, which is generated by high-power equipment or amplified by auxiliary drugs, potentially causing undesired side effects. To address current limitations, a robotic actuation-mediated therapy is developed that utilizes gentle mechanical loads to activate mechanosensitive ion channels. The resulting calcium influx precisely regulated the expression of recombinant tumor suppressor protein and death-associated protein kinase, leading to programmed apoptosis of cancer cell line through caspase-dependent pathway. In stark contrast to traditional gene therapy, the complete elimination of early- and middle-stage tumors (volume ≤ 100 mm

Indexed as

Mechanotransduction, CellularNeoplasmsRoboticsAnimalsApoptosisCell Line, TumorDisease Models, AnimalHumansMicebiomedical engineeringchemical biologymechanogeneticsprecise treatmenttumor therapy

Identifiers

PMID38509850
PMCPMC11186056

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.