ArticleCurrent drug discovery technologies2024
Article in Current drug discovery technologies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNowadays, acidity is a severe problem worldwide caused by excessive gastric acid secretion by the stomach and proximal intestine.
objectiveAntacids are drugs capable of buffering stomach acid. Therefore, in our research work, we have reported the
methodsIn this research, some magnesium complexes were synthesized and their antacid behavior was compared with marketed products. Also,
resultSpectroscopic analysis results showed that the semicarbazone ligand shows keto-enol isomerism and forms a coordinated stable complex with magnesium ions in the crystalline phase. The FT-IR results confirmed the presence of Mg-O stretching, N-H bending, and C=N stretching vibrations in Mg (II) complexes.
conclusionThe antacid activities of Mg (II) complexes were excellent as compared to the semicarbazone ligand and comparable with that of marketed antacid drugs like ENO, and Pantop-D. Insilco studies also confirmed that semicarbazone ligand and its Mg (II) complexes were both found to be fitted into the active sites of molecular targets, and Mg (II) complexes showed better binding affinities towards macromolecular as compared to semicarbazone ligand.
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