ArticleExperimental physiology2024
Age and sex differences in microvascular responses during reactive hyperaemia.
Article in Experimental physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes.Nutrients · 2025Trial
- Comparative assessment of healthy tissue oxygenation using near-infrared imaging, transcutaneous oxygen measurement, and plethysmography.Scientific reports · 2025Trial
- Effectiveness of short-term cycling interventions in older adults: a randomized trial of hypoxic, blood flow restriction, and eccentric cycling.Scientific reports · 2025Trial
- Sex comparisons across different indices of vascular health in recreationally active healthy adults.European journal of applied physiology · 2026Article
- Muscle microvascular reactivity and its associations with arterial stiffness and aortic pressures in postmenopausal women with abdominal obesity and hypertension.Journal of human hypertension · 2026Article
- Interindividual differences in dyspnea during acute hypoxic exercise in healthy adults: A single exposure to simulated altitude at ~9000 ft.Physiological reports · 2026Article
- Near-Infrared Spectroscopy in the Pathophysiology, Diagnosis, and Exercise-Based Management of Muscle Oxygenation Impairment.Diagnostics (Basel, Switzerland) · 2026Review
- Muscle oxidative capacity does not appear to influence NIRS-VOT outcomes in healthy adults.European journal of applied physiology · 2026Article
- Leg muscle microvascular function is associated with dynamic but not static balance performance in older adults.BMC geriatrics · 2026Article
- Sex differences in near-infrared spectroscopy reactive hyperemia: Influence of adipose tissue and desaturation rate.Microvascular research · 2026Article
- Microvascular arteriolar reactivity in response to skeletal muscle contractions in female and male hamsters.Physiological reports · 2025Article
- Sacral Microvascular Response in Older Adults Following Mechanical Loading Assessed by Photoplethysmography and Infrared Thermometry.International journal of environmental research and public health · 2025Observational
- Radiomic identification of anemia features in monochromatic conjunctiva photographs in school-age children.Biophotonics discovery · 2025Article
- Oxygen transport across the lifespan of male Sprague Dawley rats.Biogerontology · 2025Article
- Age and sex differences in microvascular responses during reactive hyperaemia.Experimental physiology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Microvascular impairments are typical of several cardiovascular diseases. Near-infrared spectroscopy (NIRS) combined with a vascular occlusion test provides non-invasive insights into microvascular responses by monitoring skeletal muscle oxygenation changes during reactive hyperaemia. Despite increasing interest in the effects of sex and ageing on microvascular responses, evidence remains inconsistent. Therefore, the present study aimed to investigate the effects of sex and age on microvascular responsiveness. Twenty-seven participants (seven young men and seven young women; seven older men and six older women; aged 26 ± 1, 26 ± 4, 67 ± 3 and 69 ± 4 years, respectively) completed a vascular occlusion test consisting of 5 min of arterial occlusion followed by 5 min reperfusion. Oxygenation changes in the vastus lateralis were monitored by near-infrared spectroscopy. The findings revealed that both women (referring to young and older women) and older participants (referring to both men and women) exhibited lower microvascular responsiveness. Notably, both women and older participants demonstrated reduced desaturation (-38% and -59%, respectively) and reperfusion rates (-24% and -40%, respectively) along with a narrower range of tissue oxygenation (-39% and -39%, respectively) and higher minimal tissue oxygenation levels (+34% and +21%, respectively). Women additionally displayed higher values in resting (+12%) and time-to-peak (+15%) tissue oxygenation levels. In conclusion, this study confirmed decreased microvascular responses in women and older individuals. These results emphasize the importance of considering sex and age when studying microvascular responses. Further research is needed to uncover the underlying mechanisms and clinical relevance of these findings, enabling the development of tailored strategies for preserving vascular health in diverse populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.