Evidence map›Paper›PMID 38509591›Full record

ArticleLipids in health and disease2024

Association between dietary magnesium intake and gallstones: the mediating role of atherogenic index of plasma.

Wenyi Du, Chen Yan, Yinkang Wang, Chen Song, Yunfan Li, Zhiqiang Tian, Yuan Liu, Wei Shen

Open access · goldAbstract read
In one paragraph

Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Wenyi Du *Department of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Chen Yan *Medical Imaging Centre, Tengzhou Central People's Hospital, Jining Medical College, Shandong, China.
Yinkang WangDepartment of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Chen SongDepartment of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Yunfan LiDepartment of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Zhiqiang TianDepartment of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Yuan LiuDepartment of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China. liuyuanjs@outlook.com.
Wei ShenDepartment of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China. shenweijs@outlook.com.
Nanjing Medical University · CNWuxi People's Hospital · CNJiangsu University · CNJining Medical University · CNWuxi No.2 People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDyslipidemia and abnormalities in cholesterol metabolism are commonly observed in individuals with gallstone disease. Previous research has demonstrated that dietary magnesium can influence lipid metabolism. The atherogenic index of plasma (AIP) has emerged as a novel lipid marker. This study aimed to examine the possible correlation between dietary magnesium intake and gallstones and the potential mediating role of AIP in US adults.

methodsA total of 4,841 adults were included in this study from the National Health and Nutrition Examination Survey (NHANES) conducted from 2017 to 2020. A variety of statistical techniques such as logistic regression, subgroup analysis, smoothed curve fitting, and causal mediation analysis were utilized to analyze the information collected from the participants.

resultsIn the fully adjusted model, a statistically noteworthy inverse relationship was observed between dietary magnesium intake and the presence of gallstones, as indicated by an odds ratio (OR) of 0.58 and a 95% confidence interval (CI) of (0.42, 0.81). Causal intermediary analysis revealed that the association between magnesium intake and gallstones was partially mediated by AIP, with a mediation ratio of 3.2%.

conclusionAccording to this study, dietary magnesium intake had a significant linear negative association with the prevalence of gallstones, in which AIP played a mediating role. This discovery offers novel perspectives on the prevention and management of gallstones.

Indexed as

AtherosclerosisGallstonesAdultHumansMagnesiumNutrition SurveysMagnesiumAtherogenic index of plasmaDietary magnesiumGallstonesNational health and nutrition examination survey

Identifiers

PMID38509591
PMCPMC10953275
OpenAlexW4393007456

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.