Evidence map›Paper›PMID 38509557›Full record

ArticleBMC public health2024

Evaluating the risk of conflict on recent Ebola outbreaks in Guinea and the Democratic Republic of the Congo.

Gina E C Charnley, Nathan Green, Ilan Kelman, Espoir B Malembaka, Katy A M Gaythorpe

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Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Gina E C CharnleyBloomberg School of Public Health, Johns Hopkins University, Baltimore, USA. gcharnl1@jh.edu.
Nathan GreenDepartment of Statistical Science, University College London, London, UK.
Ilan KelmanInstitute for Global Health, University College London, London, UK.
Espoir B MalembakaBloomberg School of Public Health, Johns Hopkins University, Baltimore, USA.
Katy A M GaythorpeSchool of Public Health, Imperial College London, London, UK.

Funding

Medical Research Council
6 · The paper itself

Abstract

backgroundReducing Ebola virus transmission relies on the ability to identify cases and limit contact with infected bodily fluids through biosecurity, safe sex practices, safe burial and vaccination. Armed conflicts can complicate outbreak detection and interventions due to widespread disruption to governments and populations. Guinea and the Democratic Republic of the Congo (DRC) have historically reported the largest and the most recent Ebola virus outbreaks. Understanding if conflict played a role in these outbreaks may help in identifying key risks factors to improve disease control.

methodsWe used data from a range of publicly available data sources for both Ebola virus cases and conflict events from 2018 to 2021 in Guinea and the DRC. We fitted these data to conditional logistic regression models using the Self-Controlled Case Series methodology to evaluate the magnitude in which conflict increased the risk of reported Ebola virus cases in terms of incidence rate ratio. We re-ran the analysis sub-nationally, by conflict sub-event type and tested any lagged effects.

resultsConflict was significantly associated with an increased risk of reported Ebola virus cases in both the DRC and Guinea in recent outbreaks. The effect was of a similar magnitude at 1.88- and 1.98-times increased risk for the DRC and Guinea, respectively. The greatest effects (often higher than the national values) were found in many conflict prone areas and during protest/riot-related conflict events. Conflict was influential in terms of Ebola virus risk from 1 week following the event and remained important by 10 weeks.

conclusionExtra vigilance is needed following protests and riot-related conflict events in terms of Ebola virus transmission. These events are highly disruptive, in terms of access to transportation and healthcare and are often in urban areas with high population densities. Additional public health messaging around these types of conflict events, relating to the risks and clinical symptoms may be helpful in reducing transmission. Future work should aim to further understand and quantify conflict severity and intensity, to evaluate dose-response relationships in terms of disease risk.

Indexed as

EbolavirusHemorrhagic Fever, EbolaDemocratic Republic of the CongoDisease OutbreaksGuineaHumansConflictDemocratic Republic of the CongoEbola virusGuineaOutbreaks

Identifiers

PMID38509557
PMCPMC10953285

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.