Evidence map›Paper›PMID 38509472›Full record

ArticleBMC cardiovascular disorders2024

APOE ε4 carriage associates with improved myocardial performance from adolescence to older age.

Constantin-Cristian Topriceanu, Mit Shah, Matthew Webber, Fiona Chan, Hunain Shiwani, Marcus Richards, Jonathan Schott, Nishi Chaturvedi, James C Moon, Alun D Hughes and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. The physiological effects of APOE genotype in healthy young/middle-aged individuals.Biological reviews of the Cambridge Philosophical Society · 2026
    Article
  2. Movement disorders: a brief overview from an evolutionary perspective.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Constantin-Cristian TopriceanuUCL MRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Mit ShahImperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
Matthew WebberUCL MRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Fiona ChanUCL MRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Hunain ShiwaniUCL Institute of Cardiovascular Science, University College London, London, UK.
Marcus RichardsUCL MRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Jonathan SchottUCL MRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Nishi ChaturvediUCL MRC Unit for Lifelong Health and Ageing, University College London, London, UK.
James C MoonUCL Institute of Cardiovascular Science, University College London, London, UK.
Alun D HughesUCL MRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Aroon D HingoraniUCL Institute of Cardiovascular Science, University College London, London, UK.
Declan P O'ReganImperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
Gabriella CapturUCL MRC Unit for Lifelong Health and Ageing, University College London, London, UK. gabriella.captur@ucl.ac.uk.
University College London · GBBritish Heart Foundation · GBImperial College London · GBMRC London Institute of Medical Sciences · GBMRC Unit for Lifelong Health and Ageing · GBNational Hospital for Neurology and Neurosurgery · GB

Funding

Medical Research Council MC_UP_1605/13Medical Research Council MC_UU_12019/5
6 · The paper itself

Abstract

backgroundAlthough APOE ε4 allele carriage confers a risk for coronary artery disease, its persistence in humans might be explained by certain survival advantages (antagonistic pleiotropy).

methodsCombining data from ~ 37,000 persons from three older age British cohorts (1946 National Survey of Health and Development [NSHD], Southall and Brent Revised [SABRE], and UK Biobank) and one younger age cohort (Avon Longitudinal Study of Parents and Children [ALSPAC]), we explored whether APOE ε4 carriage associates with beneficial or unfavorable left ventricular (LV) structural and functional metrics by echocardiography and cardiovascular magnetic resonance (CMR).

resultsCompared to the non-APOE ε4 group, APOE ε4 carriers had similar cardiac phenotypes in terms of LV ejection fraction, E/e', posterior wall and interventricular septal thickness, and LV mass. However, they had improved myocardial performance resulting in greater LV stroke volume generation per 1 mL of myocardium (higher myocardial contraction fraction). In NSHD (n = 1467) and SABRE (n = 1187), ε4 carriers had a 4% higher MCF (95% CI 1-7%, p = 0.016) using echocardiography. Using CMR data, in UK Biobank (n = 32,972), ε4 carriers had a 1% higher MCF 95% (CI 0-1%, p = 0.020) with a dose-response relationship based on the number of ε4 alleles. In addition, UK Biobank ε4 carriers also had more favorable radial and longitudinal strain rates compared to non APOE ε4 carriers. In ALSPAC (n = 1397), APOE ε4 carriers aged < 24 years had a 2% higher MCF (95% CI 0-5%, p = 0.059).

conclusionsBy triangulating results in four independent cohorts, across imaging modalities (echocardiography and CMR), and in ~ 37,000 individuals, our results point towards an association between ε4 carriage and improved cardiac performance in terms of LV MCF. This potentially favorable cardiac phenotype adds to the growing number of reported survival advantages attributed to the pleiotropic effects APOE ε4 carriage that might collectively explain its persistence in human populations.

Indexed as

Apolipoprotein E4Coronary Artery DiseaseAdolescentAgedAllelesApolipoproteins EChildGenotypeHumansLongitudinal StudiesMyocardiumPhenotypeApoE protein, humanApolipoprotein E4Apolipoproteins EApolipoprotein ε4Cardiovascular diseaseMyocardial contraction fraction

Identifiers

PMID38509472
PMCPMC10956279
OpenAlexW4393053898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.