Evidence map›Paper›PMID 38509421›Full record

ArticleBioprocess and biosystems engineering2024

Morinda citrifolia leaf assisted synthesis of ZnO decorated Ag bio-nanocomposites for in-vitro cytotoxicity, antimicrobial and anticancer applications.

Gopinath Venkatraman, Priyadarshini Sakthi Mohan, Puteri Shafinaz Abdul-Rahman, Faridah Sonsudin, Barathan Muttiah, Abdurahman Hajinur Hirad, Abdullah A Alarfaj, Shifa Wang

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Article in Bioprocess and biosystems engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gopinath VenkatramanUniversiti Malaya Centre for Proteomics Research, Deputy Vice-Chancellors Research and Innovation, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. gopinath87@um.edu.my.
Priyadarshini Sakthi MohanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Puteri Shafinaz Abdul-RahmanDepartment of Molecular Medicine, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Faridah SonsudinDepartment of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Barathan MuttiahCentre for Tissue Engineering and Regenerative Medicine (CTERM), Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, 56000, Kuala Lumpur, Malaysia.
Abdurahman Hajinur HiradDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. 2455, Riyadh, 11451, Saudi Arabia.
Abdullah A AlarfajDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. 2455, Riyadh, 11451, Saudi Arabia.
Shifa WangSchool of Electronic and Information Engineering, Chongqing Three Gorges University, Chongqing, 404000, Wanzhou, China.

Funding

Deanship of Scientific Research at King Saud University RG-1441-362
6 · The paper itself

Abstract

This study used Morinda citrifolia leaf (MCL) extract to synthesise Zinc oxide nanoparticles (ZnO NPs) and ZnO decorated silver nanocomposites (ZnO/Ag NCs). The synthesized nanomaterials structural morphology and crystallinity were characterized using a Field emission scanning electron microscope (FESEM) and X-ray diffraction (XRD) analysis. The antimicrobial activity of ZnO NPs and ZnO/Ag NCs was evaluated using human nosocomial bacterial pathogens. The highest antimicrobial activity was recorded for ZnO/Ag NCs at the minimum inhibitory concentration (MIC) at 80 and 100 μg/mL for Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis, Staphylococcus aureus than ZnO NPs at the MIC of 120 and 140 μg/mL for Bacillus subtilis and Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus. Furthermore, ROS detection, viability assay and bacterial membrane integrity analysis of ZnO/Ag NCs treated P. aeruginosa and S. aureus revealed the fundamental bactericidal mechanism involving cell wall, cell membrane interaction and release of cytoplasmic contents. In addition, ZnO/Ag NCs and ZnO NPs showed higher toxicity towards A549 lung cancer cells than the non-cancerous RAW264 macrophage cells, with IC

Indexed as

Antineoplastic AgentsMorindaNanocompositesPlant LeavesSilverZinc OxideA549 CellsAnimalsAnti-Bacterial AgentsAnti-Infective AgentsHumansMetal NanoparticlesMiceMicrobial Sensitivity TestsPlant ExtractsRAW 264.7 CellsAnti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsPlant ExtractsSilverZinc OxideAntibacterialCytotoxicityMetabolic activityNanocompositesReactive oxygen species

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.