Evidence map›Paper›PMID 38509393›Full record

ArticleNature biomedical engineering2024

Affinity maturation of CRISPR-engineered B cell receptors in vivo.

Abstract read
In one paragraph

Article in Nature biomedical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Toward CAR-B cells for HIV-1 therapy.Molecular therapy. Methods & clinical development · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

0 authors.

Funding

Project 4: A permanent off-switch for AAVU19AI149646 · NIAID · UNIVERSITY OF FLORIDA · PI FARZAN, MICHAEL R. · 2020 to 2024
$14.0M
Engineering CAR-B cells for an HIV-1 functional cureR01DA056771 · NIDA · UNIVERSITY OF FLORIDA · PI Michael R. Farzan · 2022 to 2026
$3.5M
In vivo transformation of chimeric antigen receptor B cells for a functional cure of HIVR01AI174277 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Hyeryun Choe, Michael R. Farzan · 2023 to 2026
$3.3M
Safe, CRISPR/Cas-free B cell editing for therapeutic applicationsR21AI178031 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI FARZAN, MICHAEL R. · 2023 to 2024
$487k
NIAID NIH HHS R01 AI174277NIAID NIH HHS R21 AI178031NIAID NIH HHS U19 AI149646NIDA NIH HHS R01 DA056771
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CRISPR-Cas SystemsReceptors, Antigen, B-CellAnimalsB-LymphocytesClustered Regularly Interspaced Short Palindromic RepeatsGene EditingHumansMiceReceptors, Antigen, B-Cell

Identifiers

PMID38509393
PMCPMC12125666

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.