ArticleNature2024
Resilient anatomy and local plasticity of naive and stress haematopoiesis.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
23.6field-weighted citation impact, top 1% of its field
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42 citing papers in PubMed, 52 citations in OpenAlex.
- Porosity-engineered long-acting protopanaxadiol microspheres prevent CDK4/6 inhibitor-induced myelosuppression.Materials today. Bio · 2026Article
- Bone marrow-inspired DLL1-presenting microparticles enhance asymmetric division and maintenance of mouse hematopoietic stem and progenitor cells.Stem cell reports · 2026Article
- With or Without You: Do Human EBIs Need a Central Macrophage?Blood red cells & iron · 2026Article
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- DNMT3A/TET2-mediated epigenetic alteration in Type-1 diabetes dysregulates the haematopoiesis.Molecular biology reports · 2026Review
- Spatial transcriptomic analyses highlight distinct erythroid niches in mice and humans.Nature genetics · 2026Article
- Resilience of the bone marrow vascular architecture to aging and hematological stress.Blood vessels, thrombosis & hemostasis · 2026Article
- Spatial instruction of tissue immunity.ImmunoHorizons · 2026Review
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- Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging.Nature communications · 2026Article
- Practical AI-based cell extraction and spatial statistics for large 3D bone marrow tissue images.Cell reports methods · 2026Article
- Effects of fatty acids and cholesterol on functions and behavior of bone marrow mesenchymal stem cells.iScience · 2026Review
- The puzzling duality of mesenchymal stem cells and adipocytes in bone marrow and ageing.npj aging · 2026Review
- Periodic Therapeutic Phlebotomy Mitigates Systemic Aging Phenotypes by Promoting Bone Marrow Function.Aging cell · 2026Article
- Rapid 3D Immunolabeling and Light Sheet Microscopy for Quantitative Analysis of Intact Tissues.Computational and structural biotechnology journal · 2026Article
- Reconstruction of hematopoietic stem cell nichesMaterials today. Bio · 2025Review
- Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells.Nature cell biology · 2025Article
- Article
- Nucleosome stability safeguards cell identity, stress resilience and healthy aging.Research square · 2025Article
- GABA produced by multiple bone marrow cell types regulates hematopoietic stem and progenitor cells.Stem cell reports · 2025Article
Corrections and comments
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Authors and funding
23 authors at 4 institutions in 2 countries.
Qingqing Wu *Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. wuqingqing@ustc.edu.cn.ORCID 0000-0002-1566-1253
Jizhou Zhang *Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Sumit KumarDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-8976-3482
Siyu ShenDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-9932-4210
Morgan KincaidDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Courtney B JohnsonDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Yanan Sophia ZhangDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Raphaël TurcotteCenter for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2257-4190
Clemens AltCenter for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Kyoko ItoRuth L. and David S. Gottesman Institute for Stem Cell, Regenerative Medicine Research, Department of Cell Biology and Stem Cell Institute, Albert Einstein College of Medicine, Bronx, NY, USA.
Shelli HomanDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Bryan E ShermanDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Tzu-Yu ShaoDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0002-2896-689X
Anastasiya SlaughterDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0003-4414-3639
Benjamin WeinhausDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Baobao SongImmunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0002-0062-2710
Marie Dominique FilippiDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-7808-0237
H Leighton GrimesDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-8162-6758
Charles P LinAdvanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Keisuke ItoRuth L. and David S. Gottesman Institute for Stem Cell, Regenerative Medicine Research, Department of Cell Biology and Stem Cell Institute, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0002-6702-9735
Sing Sing WayDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0001-8948-1952
J Matthew KofronDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Daniel LucasDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. daniel.lucas@cchmc.org.ORCID 0000-0002-0147-5425
Cincinnati Children's Hospital Medical Center · USAlbert Einstein College of Medicine · USHarvard University · USUniversity of Science and Technology of China · CN
Funding
ENVIRONMETAL CARCINOGENESIS AND MUTAGENESIST32ES007250 · NIEHS · UNIVERSITY OF CINCINNATI · PI MILLER, WILLIAM E · 1988 to 2024
$11.9MIn Vivo Sickle Cell Vasoocclusion: Adhesion MechanismsR01HL069438 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI KELLY, LIBUSHA · 2001 to 2024
$9.5MImmunological identity redefined by genetically foreign microchimeric cellsDP1AI131080 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2016 to 2020
$5.5MMechanisms of granulocyte homeostasisR01HL122661 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI H. LEIGHTON GRIMES, Nathan G. Salomonis · 2015 to 2026
$5.3MThe Roles of Lipid Metabolism in the Maintenance of Hematopoietic Stem CellsR01DK098263 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Keisuke Ito · 2013 to 2026
$5.2MXenotransplant and Genome Editing CoreU54DK126108 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Daniel Starczynowski, YI ZHENG · 2021 to 2026
$5.0MDissecting the canonical and non-canonical functions of Tet2 in hematopoietic stem cells and hematologic disordersR01HL148852 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Meelad Dawlaty, Keisuke Ito · 2019 to 2026
$4.4MNew York Consortium for Interdisciplinary Training in Kidney, Urological and Hematological Research (NYC Train KUHR)U2CDK129502 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KELVIN P DAVIES · 2022 to 2026
$3.1MSingle cell approach to uncovering factors regulating HSC division symmetry in vivoR01DK115577 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ITO, KEISUKE, LIN, CHARLES P. · 2017 to 2021
$2.9MThe role of mitochondria in hematopoietic stem cell self-renewalR01HL151654 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI FILIPPI, MARIE-DOMINIQUE · 2021 to 2024
$2.4MRole of the local vascular microenvironment in the bone marrow response to inflammationR01HL158616 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI LUCAS, DANIEL · 2021 to 2024
$2.3MSpatial Control of Myeloid DifferentiationR01HL153229 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI LUCAS, DANIEL · 2021 to 2024
$2.0MNHLBI NIH HHS R01 HL069438NHLBI NIH HHS R01 HL122661NHLBI NIH HHS R01 HL136529NHLBI NIH HHS R01 HL148852NHLBI NIH HHS R01 HL151654NHLBI NIH HHS R01 HL153229NHLBI NIH HHS R01 HL158616NHLBI NIH HHS R01 HL162649NIAID NIH HHS DP1 AI131080NIDDK NIH HHS R01 DK098263NIDDK NIH HHS R01 DK115577NIDDK NIH HHS U2C DK129502NIDDK NIH HHS U54 DK126108NIEHS NIH HHS T32 ES007250NIH HHS S10 OD023410
Abstract
The bone marrow adjusts blood cell production to meet physiological demands in response to insults. The spatial organization of normal and stress responses are unknown owing to the lack of methods to visualize most steps of blood production. Here we develop strategies to image multipotent haematopoiesis, erythropoiesis and lymphopoiesis in mice. We combine these with imaging of myelopoiesis
Indexed as
HematopoiesisHematopoietic Stem CellsStress, PhysiologicalAgingAnimalsBacterial InfectionsBlood VesselsCell LineageErythropoiesisFemaleGranulocyte Colony-Stimulating FactorHemorrhageLymphopoiesisMaleMegakaryocytesMiceGranulocyte Colony-Stimulating Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.