ArticleNature2024
Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis.
Open access · hybridAbstract readComparative Study
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
14.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Global research trends in tuberculosis drug-resistance mechanisms: a bibliometric and cross-database analysis.Frontiers in microbiology · 2026Pooled it
- Collateral sensitivity-harnessing microbial vulnerabilities as a solution to antimicrobial resistance.Molecular biology reports · 2026Review
- Pan-genomic analysis of the multi-drug resistant strains of Mycobacterium tuberculosis.World journal of microbiology & biotechnology · 2026Article
- Desiccation promotes DNA damage and rifampin resistance in Mycobacterium tuberculosis.Nature microbiology · 2026Article
- Modulation of rob expression accelerates development of antibiotic resistance in Yersinia enterocolitica.Nucleic acids research · 2026Article
- Encoded metabolic remodeling amplifies drug resistance in Mycobacterium tuberculosis.PLoS pathogens · 2026Article
- Mutations in RNA polymerase that drive the emergence of antibiotic resistance.Current opinion in microbiology · 2026Review
- The WhiA and WhiB2 transcription factors mediate theNAR molecular medicine · 2026Article
- Heterogeneity in microbial antibiotic responses: genetic basis and within-host evolution.Trends in genetics : TIG · 2026Review
- Genome scale CRISPRi reveals both shared and strain-specific vulnerabilities in genetically diverse drug-resistant strains of Mycobacterium tuberculosis.Nature communications · 2026Article
- Transcription attenuation amplifies collateral vulnerabilities in rifampicin-resistant Mycobacterium tuberculosis.Nature microbiology · 2026Article
- Review
- Limited contribution of compensatory mutations to MDR/RR-TB clustering in Hunan Province, China: a population-based whole-genome sequencing study.Microbiology spectrum · 2026Article
- Uncovering actionable trade-offs of antifungal resistance in a yeast pathogen.Molecular systems biology · 2026Article
- Cell-free genomics reveals fundamental regulatory principles of the Mycobacterium tuberculosis transcription cycle.Molecular cell · 2026Article
- Characterization of pulmonary tuberculosis in high-altitude region using nanopore targeted sequencing.BMC microbiology · 2026Article
- Pitaya‑inspired compartmentalized microspheres with natural tannic acid-copper coating orchestrate smart release of ions and multi-drugs for synergistic treatment of infected bone defects.Regenerative biomaterials · 2026Article
- Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas.Nature microbiology · 2026Article
- Molecular insights into antimicrobial resistance in human bacterial pathogens: mechanisms, resistance genes, and translational diagnostic applications.Frontiers in microbiology · 2026Review
- Mycobacterium tuberculosis uses intrinsically disordered, fast evolving proteins to interact with conserved host factors.Genome biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Kathryn A Eckartt *Laboratory of Host-Pathogen Biology, The Rockefeller University, New York, NY, USA.
Madeleine Delbeau *Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA.
Vanisha Munsamy-GovenderLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, NY, USA.
Michael A DeJesusLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-3867-0299
Zachary A AzadianLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, NY, USA.
Abhijna K ReddyLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, NY, USA.
Joshua ChandananiLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-2671-2412
Nicholas C PoultonLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, NY, USA.
Stefany Quiñones-GarciaLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, NY, USA.
Barbara BoschLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, NY, USA.
Robert LandickDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-5042-0383
Elizabeth A CampbellLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA. campbee@rockefeller.edu.ORCID 0000-0002-1332-128X
Jeremy M RockLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, NY, USA. rock@rockefeller.edu.ORCID 0000-0002-9310-951X
Rockefeller University · USUniversity of Wisconsin–Madison · US
Funding
Study of M. tuberculosis under human host selection to identify virulence and barrier lipids (Project 1)U19AI162584 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2021 to 2025
$13.5MSTRUCTURE/FUNCTION OF TRANSCRIPTION COMPLEX RNA HAIRPINSR01GM038660 · NIGMS · WASHINGTON UNIVERSITY · PI Robert Landick · 1992 to 2026
$12.2MStructure/function analyses of essential mycobacterial transcription regulatorsR01GM114450 · NIGMS · ROCKEFELLER UNIVERSITY · PI CAMPBELL, ELIZABETH A · 2015 to 2023
$3.4MImmunity and Infectious DiseaseT32AI070084 · NIAID · ROCKEFELLER UNIVERSITY · PI Michel C Nussenzweig · 2008 to 2026
$3.3MTowards a molecular understanding of persistent tuberculosis infectionDP2AI144850 · NIAID · ROCKEFELLER UNIVERSITY · PI ROCK, JEREMY MICHAEL · 2018 to 2018
$2.5MGenetics and Cell Biology Training ProgramT32GM144299 · NIGMS · ROCKEFELLER UNIVERSITY · PI Viviana I Risca, Tim Stearns · 2022 to 2026
$2.1MStructural and functional studies of the mycobacterial transcription cycleR35GM151879 · NIGMS · ROCKEFELLER UNIVERSITY · PI ELIZABETH A CAMPBELL · 2024 to 2026
$1.4MNIAID NIH HHS DP2 AI144850NIAID NIH HHS T32 AI070084NIAID NIH HHS U19 AI162584NIGMS NIH HHS R01 GM038660NIGMS NIH HHS R01 GM114450NIGMS NIH HHS R35 GM151879NIGMS NIH HHS T32 GM144299
Abstract
Drug-resistant bacteria are emerging as a global threat, despite frequently being less fit than their drug-susceptible ancestors
Indexed as
Bacterial ProteinsDrug Resistance, BacterialEvolution, MolecularGenetic FitnessMycobacterium tuberculosisRifampinConserved SequenceDNA-Directed RNA PolymerasesEscherichia coliEscherichia coli ProteinsGenomicsHumansMutationPeptide Elongation FactorsTranscription FactorsTuberculosis, Multidrug-ResistantBacterial ProteinsDNA-Directed RNA PolymerasesEscherichia coli ProteinsNusG protein, E coliPeptide Elongation FactorsRifampinTranscription Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.