ArticleNature2024
A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 307 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
307citing papers in PubMed, 4 pooled it
130.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
307 citing papers in PubMed, 4 syntheses or guidelines pooled it, 337 citations in OpenAlex.
- The Hidden Link Between Intestinal Helminthiasis, Gut Microbiome Alterations, and Colorectal Cancer Risk: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Coordinated oral-gut microbiota relocation in connective tissue diseases: a systematic review.Frontiers in immunology · 2026Pooled it
- The presence and relative abundance of salivary Fusobacterium nucleatum are not associated with colorectal cancer: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Meta-analysis of gut microbiome reveals patterns of dysbiosis in colorectal cancer patients.Journal of medical microbiology · 2025Pooled it
- An oral-gut microbial metabolite linksGut microbes · 2026Article
- Pangenome analysis reveals both niche-specific "specialists" and microbial "side hustlers" in colorectal cancer microbiomes.Gut microbes · 2026Article
- Article
- The role of adhesins ofGut microbes · 2026Review
- metaFun: An analysis pipeline for metagenomic big data with fast and unified functional searches.Gut microbes · 2026Article
- Full-length 16S rRNA nanopore sequencing enables species resolution ofGut microbes · 2026Article
- Microbiota as a modulator of drug response: targeting microbial-drug crosstalk in cancer therapy.Gut microbes · 2026Review
- Review
- Metabolites and cancer metastasis.Oncogene · 2026Review
- Fusobacterium nucleatum enhances enterotoxigenic Bacteroides fragilis-mediated neuron loss and intestinal motility dysfunction.Nature microbiology · 2026Article
- Host-Microbe Mechanisms of Fusobacterium nucleatum in Colorectal Cancer.Molecular oral microbiology · 2026Review
- Shaping the future of early-onset colorectal cancer prevention.Nature reviews. Cancer · 2026Review
- Association between Clostridium septicum and Streptococcus gallolyticus bacteremia and colorectal neoplasms.Surgery today · 2026Article
- Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- From trees to graphs: rethinking phylogeny in microbiome prediction.Applied and environmental microbiology · 2026Article
- Integrative microbiome and functional profiling identifymSystems · 2026Article
247 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 7 institutions in 4 countries.
Martha Zepeda-RiveraVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Samuel S MinotData Core, Shared Resources, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0003-1639-3905
Heather BouzekVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Hanrui WuHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Aitor Blanco-MíguezDepartment of Computational, Cellular and Integrative Biology, University of Trento, Trento, Italy.ORCID 0000-0001-7386-5572
Paolo ManghiDepartment of Computational, Cellular and Integrative Biology, University of Trento, Trento, Italy.ORCID 0000-0003-0846-6529
Dakota S JonesVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Kaitlyn D LaCourseHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Ying WuVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Elsa F McMahonVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Soon-Nang ParkKorean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University, Gwangju, Republic of Korea.
Yun K LimKorean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University, Gwangju, Republic of Korea.
Andrew G KempchinskyHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Amy D WillisDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Sean L CottonForsyth Institute, Cambridge, MA, USA.
Susan C YostForsyth Institute, Cambridge, MA, USA.
Ewa SicinskaDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
Joong-Ki KookKorean Collection for Oral Microbiology and Department of Oral Biochemistry, School of Dentistry, Chosun University, Gwangju, Republic of Korea.ORCID 0000-0003-2628-2870
Floyd E DewhirstForsyth Institute, Cambridge, MA, USA.ORCID 0000-0003-4427-7928
Nicola SegataDepartment of Computational, Cellular and Integrative Biology, University of Trento, Trento, Italy.
Susan BullmanHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. sbullman@fredhutch.org.ORCID 0000-0002-7713-0810
Christopher D JohnstonVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. johnston@fredhutch.org.ORCID 0000-0002-6765-2383
Fred Hutch Cancer Center · USChosun University · KRUniversity of Trento · ITCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZADana-Farber Cancer Institute · USHarvard University · USUniversity of Washington · US
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4MThe SyngenicDNA and μPOET Platform: Overcoming Innate Barriers to Genetic Engineering in Bacteria.R01DE027850 · NIDCR · FRED HUTCHINSON CANCER RESEARCH CENTER · PI JOHNSTON, CHRISTOPHER D · 2017 to 2021
$4.9MStatistical methods to enhance reproducible microbiome discoveryR35GM133420 · NIGMS · UNIVERSITY OF WASHINGTON · PI Amy D Willis · 2019 to 2026
$2.8MHigh-Performance Compute Cluster for Comprehensive Cancer and Infectious Diseases ResearchS10OD028685 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BRADLEY, PHILIP · 2020 to 2020
$2.0MThe role of Fusobacterium in colorectal cancer treatment, tumor ecology and chemotherapeutic efficacyR00CA229984 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BULLMAN, SUSAN · 2019 to 2021
$718kAdvanced genetic systems for Fusobacterium nucleatum in oral and extra-oral pathologiesR21DE033533 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI JOHNSTON, CHRISTOPHER D · 2023 to 2023
$481kNCI NIH HHS P30 CA015704NCI NIH HHS R00 CA229984NIDCR NIH HHS R01 DE027850NIDCR NIH HHS R21 DE033533NIGMS NIH HHS R35 GM133420NIH HHS S10 OD028685
Abstract
Fusobacterium nucleatum (Fn), a bacterium present in the human oral cavity and rarely found in the lower gastrointestinal tract of healthy individuals
Indexed as
Colorectal NeoplasmsFusobacterium nucleatumAdenomaAnimalsCase-Control StudiesFecesFemaleGastrointestinal TractGenome, BacterialHumansMiceMouth
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.