Evidence map›Paper›PMID 38509349›Full record

ArticleNature chemical biology2024

Sulfide oxidation promotes hypoxic angiogenesis and neovascularization.

Roshan Kumar, Victor Vitvitsky, Apichaya Sethaudom, Rashi Singhal, Sumeet Solanki, Sydney Alibeckoff, Harrison L Hiraki, Hannah N Bell, Anthony Andren, Brendon M Baker and 3 more

Open access · greenAbstract read
In one paragraph

Article in Nature chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. HBiochemistry · 2026
    Article
  9. Article
  10. Power and poison: The intersections of HThe Journal of biological chemistry · 2025
    Review
  11. Hydrogen sulfide/polysulfides signaling and neuronal diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  12. Gut sulfide metabolism modulates behavior and brain bioenergetics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. HThe Journal of biological chemistry · 2025
    Article
  14. Article
  15. SQOR as a metabolic rheostat of HFrontiers in cell and developmental biology · 2025
    Review
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Roshan KumarDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.
Victor VitvitskyDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.
Apichaya SethaudomDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.
Rashi SinghalDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Sumeet SolankiDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Sydney AlibeckoffDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.
Harrison L HirakiDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6199-0744
Hannah N BellDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Anthony AndrenDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Brendon M BakerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Yatrik M ShahDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2487-4816
Ruma BanerjeeDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA. rbanerje@umich.edu.ORCID http://orcid.org/0000-0001-8332-3275
University of Michigan · US

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Control of iron absorption by intestinal HIF2 in iron and hematological disordersR01DK095201 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2012 to 2025
$5.7M
The role of HIF2alpha in colon carcinogenesisR01CA148828 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2010 to 2025
$5.2M
Michigan Chemistry-Biology Interface Training ProgramT32GM132046 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Emily E Scott, Wenjing Wang · 2019 to 2026
$4.1M
Sulfide Oxidation and SignalingR35GM130183 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUMA V BANERJEE · 2019 to 2026
$3.6M
Understanding the mechanisms of iron addiction in colon cancerR01CA245546 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2020 to 2024
$2.3M
Stromal metabolism promotes therapeutic resistance in pancreatic cancerR01CA248160 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYSSIOTIS, COSTAS ANDREAS · 2020 to 2024
$2.0M
Angiogenic hydrogel composites for microvascular integration of organoid graftsR01EB030474 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKER, BRENDON M · 2021 to 2024
$1.4M
NCI NIH HHS R01 CA148828NCI NIH HHS R01 CA245546NCI NIH HHS R01 CA248160NIBIB NIH HHS R01 EB030474NIDDK NIH HHS R01 DK095201NIGMS NIH HHS R35 GM130183NIGMS NIH HHS T32 GM007863NIGMS NIH HHS T32 GM132046U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA148828U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA245546U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA248160U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM130183
6 · The paper itself

Abstract

Angiogenic programming in the vascular endothelium is a tightly regulated process for maintaining tissue homeostasis and is activated in tissue injury and the tumor microenvironment. The metabolic basis of how gas signaling molecules regulate angiogenesis is elusive. Here, we report that hypoxic upregulation of ·NO in endothelial cells reprograms the transsulfuration pathway to increase biogenesis of hydrogen sulfide (H

Indexed as

Hydrogen SulfideNeovascularization, PathologicOxidation-ReductionAngiogenesisAnimalsCell ProliferationEndothelial CellsHumansHuman Umbilical Vein Endothelial CellsHypoxiaMiceMice, Inbred C57BLMice, KnockoutNeovascularization, PhysiologicSulfidesHydrogen SulfideSulfides

Identifiers

PMID38509349
PMCPMC11584973
OpenAlexW4393004154

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.