ArticleNature neuroscience2024
Co-dependent excitatory and inhibitory plasticity accounts for quick, stable and long-lasting memories in biological networks.
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Homeostatic Plasticity Enables Stable yet Tunable Neuronal Assemblies.bioRxiv : the preprint server for biology · 2026Article
- An integratediScience · 2026Article
- Neuroligin-2-Dependent Adhesion Defines a Molecular Checkpoint for Inhibitory Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Competitive interactions shape mammalian brain network dynamics and computation.Nature neuroscience · 2026Article
- Noradrenaline causes a spread of association in the hippocampal cognitive map.Nature communications · 2026Article
- Dendritic heterosynaptic plasticity arises from calcium-based input learning.Communications biology · 2026Article
- Sharpened Visual Memory Representations Are Reflected in Inferotemporal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Correlative voltage imaging and cryo-electron tomography bridge neuronal activity and molecular structure.Nature communications · 2025Article
- Interactions between homeostatic plasticity and statistical learning: A role for inhibition.Current opinion in neurobiology · 2025Review
- Heterogeneous synaptic homeostasis: A novel mechanism boosting information propagation in the cortex.PLoS computational biology · 2025Article
- Taming the chaos gently: a predictive alignment learning rule in recurrent neural networks.Nature communications · 2025Article
- Balancing complexity, performance and plausibility to meta learn plasticity rules in recurrent spiking networks.PLoS computational biology · 2025Article
- Synaptic facilitation and learning of multiplexed neural signals.Frontiers in network physiology · 2025Article
- Excitatory/Inhibitory balance in autism spectrum disorders: Integrating genetic, neurotransmitter and computational perspectives.AIMS neuroscience · 2025Review
- Structural influences on synaptic plasticity: The role of presynaptic connectivity in the emergence of E/I co-tuning.PLoS computational biology · 2024Article
- Synapse-type-specific competitive Hebbian learning forms functional recurrent networks.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease.Frontiers in cellular neuroscience · 2024Article
- Interactions of transcranial magnetic stimulation with brain oscillations: a narrative review.Frontiers in systems neuroscience · 2024Review
- Clinical parameters affect the structure and function of superficial pyramidal neurons in the adult human neocortex.Brain communications · 2024Article
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Authors and funding
2 authors.
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Abstract
The brain's functionality is developed and maintained through synaptic plasticity. As synapses undergo plasticity, they also affect each other. The nature of such 'co-dependency' is difficult to disentangle experimentally, because multiple synapses must be monitored simultaneously. To help understand the experimentally observed phenomena, we introduce a framework that formalizes synaptic co-dependency between different connection types. The resulting model explains how inhibition can gate excitatory plasticity while neighboring excitatory-excitatory interactions determine the strength of long-term potentiation. Furthermore, we show how the interplay between excitatory and inhibitory synapses can account for the quick rise and long-term stability of a variety of synaptic weight profiles, such as orientation tuning and dendritic clustering of co-active synapses. In recurrent neuronal networks, co-dependent plasticity produces rich and stable motor cortex-like dynamics with high input sensitivity. Our results suggest an essential role for the neighborly synaptic interaction during learning, connecting micro-level physiology with network-wide phenomena.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.