Evidence map›Paper›PMID 38509305›Full record

ArticleJournal of bone and mineral metabolism2024

History of fragility fracture is associated with cardiovascular mortality in hemodialysis patients: the Q-Cohort study.

Naoki Haruyama, Masaru Nakayama, Shunsuke Yamada, Shigeru Tanaka, Hiroto Hiyamuta, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Takanari Kitazono, Toshiaki Nakano

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Article in Journal of bone and mineral metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Bone Health, Fragility Fractures, and the Hand Surgeon.Journal of hand surgery global online · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Naoki HaruyamaDivision of Nephrology, Department of Internal Medicine, NHO Kyushu Medical Center, Fukuoka, Japan.
Masaru NakayamaDivision of Nephrology, Department of Internal Medicine, NHO Kyushu Medical Center, Fukuoka, Japan.
Shunsuke YamadaDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shigeru TanakaDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Hiroto HiyamutaDivision of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Masatomo TaniguchiFukuoka Renal Clinic, Fukuoka, Japan.
Masanori TokumotoDivision of Nephrology and Dialysis Center, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.
Kazuhiko TsuruyaDepartment of Nephrology, Nara Medical University, Kashihara, Nara, Japan.
Takanari KitazonoDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Toshiaki NakanoDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. nakano.toshiaki.455@m.kyushu-u.ac.jp.ORCID http://orcid.org/0000-0001-9235-5615

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn patients undergoing dialysis, major bone fracture is associated with a high risk of mortality, including death of cardiovascular (CV) origin. In the present study, we aimed to determine whether a history of fragility fracture is a predictor of CV death in patients undergoing hemodialysis with long-term follow-up. MATERIALS AND

methodsIn total, 3499 patients undergoing hemodialysis were analyzed for 10 years. We evaluated the history of fragility fracture in each patient at enrollment. The primary outcome was CV death. A Cox proportional hazard model and a competing risk approach were applied to determine the association between a history of fragility fracture and CV death.

resultsA total of 346 patients had a history of fragility fracture at enrollment. During a median follow-up of 8.8 years, 1730 (49.4%) patients died. Among them, 621 patients experienced CV death. Multivariable Cox analyses after adjustment for confounding variables showed that a history of fragility fracture was associated with CV death (hazard ratio, 1.47; 95% confidence interval, 1.16-1.85). In the Fine-Gray regression model, a history of fragility fracture was an independent risk factor for CV death (subdistribution hazard ratio, 1.36; 95% confidence interval, 1.07-1.72).

conclusionIn a large cohort of patients undergoing hemodialysis, a history of fragility fracture was an independent predictor of CV death.

Indexed as

Cardiovascular DiseasesFractures, BoneCause of DeathCohort StudiesHumansRenal DialysisRisk FactorsBone fractureBone-vascular axisCardiovascular diseaseHemodialysisMortality

Identifiers

PMID38509305

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.