Evidence map›Paper›PMID 38509265›Full record

ArticleScientific reports2024

222 nm far-UVC light markedly reduces the level of infectious airborne virus in an occupied room.

Manuela Buonanno, Norman J Kleiman, David Welch, Raabia Hashmi, Igor Shuryak, David J Brenner

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Managing infectious aerosols to counter engineered pandemics: Current recommendations and future research.Risk analysis : an official publication of the Society for Risk Analysis · 2025
    Guideline
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
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  10. Study on the Effectiveness of a Copper Electrostatic Filtration System "Aerok 1.0" for Air Disinfection.International journal of environmental research and public health · 2024
    Article
  11. Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manuela Buonanno *Center for Radiological Research, Columbia University Irving Medical Center, 630 West 168th St., New York, NY, 10032, USA. mb3591@cumc.columbia.edu.
Norman J Kleiman *Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA.
David Welch *Center for Radiological Research, Columbia University Irving Medical Center, 630 West 168th St., New York, NY, 10032, USA.
Raabia HashmiCenter for Radiological Research, Columbia University Irving Medical Center, 630 West 168th St., New York, NY, 10032, USA.
Igor ShuryakCenter for Radiological Research, Columbia University Irving Medical Center, 630 West 168th St., New York, NY, 10032, USA.
David J BrennerCenter for Radiological Research, Columbia University Irving Medical Center, 630 West 168th St., New York, NY, 10032, USA. djb3@cumc.columbia.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An emerging intervention for control of airborne-mediated pandemics and epidemics is whole-room far-UVC (200-235 nm). Laboratory studies have shown that 222-nm light inactivates airborne pathogens, potentially without harm to exposed occupants. While encouraging results have been reported in benchtop studies and in room-sized bioaerosol chambers, there is a need for quantitative studies of airborne pathogen reduction in occupied rooms. We quantified far-UVC mediated reduction of aerosolized murine norovirus (MNV) in an occupied mouse-cage cleaning room within an animal-care facility. Benchtop studies suggest that MNV is a conservative surrogate for airborne viruses such as influenza and coronavirus. Using four 222-nm fixtures installed in the ceiling, and staying well within current recommended regulatory limits, far-UVC reduced airborne infectious MNV by 99.8% (95% CI: 98.2-99.9%). Similar to previous room-sized bioaerosol chamber studies on far-UVC efficacy, these results suggest that aerosolized virus susceptibility is significantly higher in room-scale tests than in bench-scale laboratory studies. That said, as opposed to controlled laboratory studies, uncertainties in this study related to airflow patterns, virus residence time, and dose to the collected virus introduce uncertainty into the inactivation estimates. This study is the first to directly demonstrate far-UVC anti-microbial efficacy against airborne pathogens in an occupied indoor location.

Indexed as

Communicable DiseasesCoronavirus InfectionsNorovirusVirusesAnimalsDisinfectionEnvironment, ControlledMiceUltraviolet Rays

Identifiers

PMID38509265
PMCPMC10954628

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.