ReviewNPJ science of learning2024
Utilizing epigenetics to study the shared nature of development and biological aging across the lifespan.
Review in NPJ science of learning, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Physiological Age and Homeostatic Dysregulation Following Child Maltreatment in Youth.Molecular psychiatry · 2026Article
- Residential exposure to deadly gun violence and accelerated biological aging in a national sample of U.S. adolescents.SSM - population health · 2026Article
- Probing buccal-customized epigenetic clocks to investigate socioeconomic and health disparities.GeroScience · 2026Article
- Community threat, positive parenting, and accelerated epigenetic aging: Longitudinal links from childhood to adolescence.Child development · 2026Article
- MicroBayesAge: a maximum likelihood approach to predict epigenetic age using microarray data.GeroScience · 2026Article
- Salivary DNA methylation and pubertal development in adolescents.Scientific reports · 2025Article
- The High-Risk Model of Threat Perception Modulates Learning of Placebo and Nocebo Effects and Functional Somatic Disorders.Brain sciences · 2025Review
- Epigenetic age acceleration in Turner and Klinefelter syndrome: Correlations with clinical aging markers.Clinical epigenetics · 2025Article
- The social context of educational effort - implications for psychological and physiological health in adolescence.Psychoneuroendocrinology · 2025Article
- Linked emergence of racial disparities in mental health and epigenetic biological aging across childhood and adolescence.Molecular psychiatry · 2025Article
- Is virtue its own reward? Moral identity, empathy, and volunteering during adolescence as predictors of subsequent epigenetic aging.Applied psychology. Health and well-being · 2025Article
- Applying blood-derived epigenetic algorithms to saliva: cross-tissue similarity of DNA-methylation indices of aging, physiology, and cognition.Clinical epigenetics · 2025Article
- Living in endemic area for infectious diseases is associated to differences in immunosenescence and inflammatory signatures.Frontiers in immunology · 2025Article
- Impact of the environmental pollution on cardiovascular diseases: From epidemiological to molecular evidence.Heliyon · 2024Review
- Applied pharmacogenetics to predict response to treatment of first psychotic episode: study protocol.Frontiers in psychiatry · 2024Article
- Stability of Aging- and Cognition-Related Methylation Profile Scores Across Two Waves in Children and Adolescents.Child developmentArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, biological aging has been quantified in DNA-methylation samples of older adults and applied as so-called "methylation profile scores" (MPSs) in separate target samples, including samples of children. This nascent research indicates that (1) biological aging can be quantified early in the life course, decades before the onset of aging-related disease, (2) is affected by common environmental predictors of childhood development, and (3) shows overlap with "developmental processes" (e.g., puberty). Because the MPSs were computed using algorithms developed in adults, these studies indicate a molecular link between childhood environments, development, and adult biological aging. Yet, if MPSs can be used to connect development and aging, previous research has only traveled one way, deriving MPSs developed in adults and applying them to samples of children. Researchers have not yet quantified epigenetic measures that reflect the pace of child development, and tested whether resulting MPSs are associated with physical and psychological aging. In this perspective I posit that combining measures of biological aging with new quantifications of child development has the power to address fundamental questions about life span: How are development and experience in childhood related to biological aging in adulthood? And what is aging?
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.