Evidence map›Paper›PMID 38509098›Full record

ArticleNature communications2024

Structural basis of ligand recognition and design of antihistamines targeting histamine H

Ruixue Xia, Shuang Shi, Zhenmei Xu, Henry F Vischer, Albert D Windhorst, Yu Qian, Yaning Duan, Jiale Liang, Kai Chen, Anqi Zhang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  3. Article
  4. Article
  5. Molecular mechanism of ligand recognition and activation of lysophosphatidic acid receptor LPAR6.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Ruixue Xia *Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Shuang Shi *Department of Medicinal Chemistry, Amsterdam Institute for Molecular Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HV, Amsterdam, The Netherlands.ORCID 0009-0005-0027-5279
Zhenmei XuLaboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Henry F VischerDepartment of Medicinal Chemistry, Amsterdam Institute for Molecular Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HV, Amsterdam, The Netherlands.ORCID 0000-0002-0184-6337
Albert D WindhorstDepartment of Radiology and Nuclear Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.
Yu QianLaboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Yaning DuanLaboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Jiale LiangLaboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Kai ChenLaboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Anqi ZhangSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Changyou GuoSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Rob LeursDepartment of Medicinal Chemistry, Amsterdam Institute for Molecular Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HV, Amsterdam, The Netherlands. r.leurs@vu.nl.ORCID 0000-0003-1354-2848
Yuanzheng HeLaboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China. ajian.he@hit.edu.cn.ORCID 0000-0001-9131-140X
Harbin Institute of Technology · CNVrije Universiteit Amsterdam · NLAmsterdam UMC Location Vrije Universiteit Amsterdam · NL

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32070048
6 · The paper itself

Abstract

The histamine H

Indexed as

Drug Inverse AgonismHistamineImidazolesHistamine AntagonistsLigandsReceptors, G-Protein-CoupledReceptors, HistamineReceptors, Histamine H4ThioureaclobenpropitHistamineHistamine AntagonistsImidazolesLigandsReceptors, G-Protein-CoupledReceptors, HistamineReceptors, Histamine H4Thiourea

Identifiers

PMID38509098
PMCPMC10954740
OpenAlexW4392989242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.