ArticleScientific reports2024
Pediatric perforated appendicitis diagnosis based on the C-reactive protein/prealbumin ratio.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 1 citations in OpenAlex.
- Prevalence and Preoperative Characteristics Associated with Complicated Appendicitis Among Children Undergoing Appendectomy in Southwestern Saudi Arabia: A Hospital-Based Cross-Sectional Study.Children (Basel, Switzerland) · 2026Article
- Preoperative Inflammatory Markers and Sonographic Free Peritoneal Fluid in Relation to Histopathologically Confirmed Appendiceal Perforation in Children: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Predicting Complicated Appendicitis: What Can Machine Learning Add?Diagnostics (Basel, Switzerland) · 2026Article
- Nutritional Status as a Risk Factor for Appendiceal Perforation in Pediatric Acute Appendicitis: Systematic Review.Children (Basel, Switzerland) · 2026Review
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6 authors at 1 institution in 1 country.
Funding
Abstract
Pediatric perforated appendicitis, prone to multiple complications, necessitates identifying potential serum biomarkers for early diagnosis and intervention. A cross-sectional study was conducted on patients under 16 with acute appendicitis, admitted to Hainan Women and Children's Medical Center from January 2019 to July 2023. The patients were categorized into perforated and non-perforated groups. Among the 313 included patients, 106 (33.87%, 95% CI 28.59-39.14%) developed perforation. The C-reactive protein to prealbumin ratio (CPA) showed a significant difference between the perforated and non-perforated groups [6.63 (2.9-13.02) vs. 0.7 (0.11-2.18), p < 0.001]. The AUC of CPA on the ROC curve was 0.691 (95% CI 0.513-0.869, p = 0.084) in patients under 4. In patients aged 4-9, the sensitivity of CPA > 3 predicting perforation was 76.2%, with a specificity of 81.6%, and an AUC of 0.816 (95% CI 0.747-0.886, p < 0.001). For patients aged 9-16, the sensitivity of CPA > 2.2 predicting perforation was 85%, with a specificity of 85.7%, and an AUC of 0.919 (95% CI 0.859-0.979, p < 0.001). CPA > 3 and CPA > 2.2 can predict perforated appendicitis in patients aged 4-9 and 9-16, respectively.
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