ArticleInternational journal of epidemiology2024
Alcohol consumption and the risk of all-cause and cause-specific mortality-a linear and nonlinear Mendelian randomization study.
Article in International journal of epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Wine consumption, Mediterranean diet, and cardiovascular risk in two Spanish cohorts.European heart journal · 2026Trial
- A large randomized trial assessing alcohol cessation versus moderation on clinical events: UNATI.European journal of epidemiology · 2026Trial
- Alcohol consumption and cause-specific mortality in older men: Whitehall-1 study of London civil servants.European journal of epidemiology · 2026Article
- Identifying drinking patterns in a middle-aged population and their association with coronary heart disease, stroke, and all-cause mortality risk: the Danish Health Examination Survey.European journal of public health · 2026Article
- Widespread genetic effect heterogeneity impacts bias and power in nonlinear Mendelian randomization.medRxiv : the preprint server for health sciences · 2026Article
- Global Burden of Alcoholic Cardiomyopathy in Adults Aged 60 and Older From 1990 to 2021: A Secondary Analysis of Global Burden of Disease 2021 Data.Health science reports · 2026Article
- The Unfinished Debate on Wine and Other Alcoholic Beverages: Conflicting Evidence, Public Health Messages and the Missing Trial.Nutrients · 2026Review
- Diagnostic utility of two-dimensional speckle tracking imaging in detecting subclinical left ventricular systolic dysfunction in patients with alcohol-related disorders.Quantitative imaging in medicine and surgery · 2026Article
- Demographic variation in weekly alcohol use across countries in the Global Flourishing Study.Communications medicine · 2026Article
- Alcohol, the Mediterranean Diet and Cardiovascular Risks: Where is the New Evidence?European cardiology · 2026Review
- Can alcohol use explain the increase in educational inequalities in all-cause mortality after 2010 in the USA? A three-way interaction analysis.Addiction (Abingdon, England) · 2026Article
- Stratification-based instrumental variable analysis framework for nonlinear effect analysis.Biostatistics (Oxford, England) · 2025Article
- Alcohol consumption and risk of cancer: a Mendelian randomization analysis of four biobanks and consortium data.BMC medicine · 2025Article
- Alcohol consumption reported on routine healthcare screenings is associated with all-cause mortality in primary care patients: A retrospective cohort study.Alcohol, clinical & experimental research · 2025Article
- Analyzing complex traits and diseases using GxE PRS: genotype-environment interaction in polygenic risk score models.Journal of human genetics · 2025Article
- Three decades of the Mediterranean diet pyramid: A narrative review of its history, evolution, and advances.The American journal of clinical nutrition · 2025Article
- Unhealthy alcohol use and risk of coronary heart disease among young and middle-aged adults.American journal of preventive cardiology · 2025Article
- Still rethinking the J-shaped curve: A commentary on Kember et al., 2024.Alcohol, clinical & experimental research · 2025Article
- Mechanisms of Acetaldehyde-Induced Organ Injury via Impairment of Vascular Endothelial Cells.Vascular health and risk management · 2025Review
- Effects of alcohol consumption from early adolescence on lung function and development of COPD - a retrospective cohort study.European clinical respiratory journal · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundMany observational studies support light-to-moderate alcohol intake as potentially protective against premature death. We used a genetic approach to evaluate the linear and nonlinear relationships between alcohol consumption and mortality from different underlying causes.
methodsWe used data from 278 093 white-British UK Biobank participants, aged 37-73 years at recruitment and with data on alcohol intake, genetic variants, and mortality. Habitual alcohol consumption was instrumented by 94 variants. Linear Mendelian randomization (MR) analyses were conducted using five complementary approaches, and nonlinear MR analyses by the doubly-ranked method.
resultsThere were 20 834 deaths during the follow-up (median 12.6 years). In conventional analysis, the association between alcohol consumption and mortality outcomes was 'J-shaped'. In contrast, MR analyses supported a positive linear association with premature mortality, with no evidence for curvature (Pnonlinearity ≥ 0.21 for all outcomes). The odds ratio [OR] for each standard unit increase in alcohol intake was 1.27 (95% confidence interval [CI] 1.16-1.39) for all-cause mortality, 1.30 (95% CI 1.10-1.53) for cardiovascular disease, 1.20 (95% CI 1.08-1.33) for cancer, and 2.06 (95% CI 1.36-3.12) for digestive disease mortality. These results were consistent across pleiotropy-robust methods. There was no clear evidence for an association between alcohol consumption and mortality from respiratory diseases or COVID-19 (1.32, 95% CI 0.96-1.83 and 1.46, 95% CI 0.99-2.16, respectively; Pnonlinearity ≥ 0.21).
conclusionHigher levels of genetically predicted alcohol consumption had a strong linear association with an increased risk of premature mortality with no evidence for any protective benefit at modest intake levels.
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