Evidence map›Paper›PMID 38508727›Full record

ArticleExperimental animals2024

Transient receptor potential vanilloid 1 interacts with Toll-like receptor 4 (TLR4)/cluster of differentiation 14 (CD14) signaling pathway in lipopolysaccharide-mediated inflammation in macrophages.

Julia Chu-Ning Hsu, Hsu-Wen Tseng, Chia-Hui Chen, Tzong-Shyuan Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental animals, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Julia Chu-Ning HsuDepartment of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, 145, Xingda Road, South District, Taichung 402202, Taiwan.
Hsu-Wen TsengDepartment of Physiology, School of Medicine, National Yang-Ming University, 155, Sec. 2, Linong Street, Taipei 112304, Taiwan.
Chia-Hui ChenGraduate Institute and Department of Physiology, College of Medicine, National Taiwan University, 1, Sec. 1, Jen-Ai Road, Taipei 100233, Taiwan.
Tzong-Shyuan LeeGraduate Institute and Department of Physiology, College of Medicine, National Taiwan University, 1, Sec. 1, Jen-Ai Road, Taipei 100233, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient receptor potential vanilloid 1 (TRPV1), a ligand-gated cation channel, is a receptor for vanilloids on sensory neurons and is also activated by capsaicin, heat, protons, arachidonic acid metabolites, and inflammatory mediators on neuronal or non-neuronal cells. However, the role of the TRPV1 receptor in pro-inflammatory cytokine secretion and its potential regulatory mechanisms in lipopolysaccharide (LPS)-induced inflammation has yet to be entirely understood. To investigate the role and regulatory mechanism of the TRPV1 receptor in regulating LPS-induced inflammatory responses, bone marrow-derived macrophages (BMDMs) harvested from wild-type (WT) and TRPV1 deficient (Trpv1

Indexed as

InflammationLipopolysaccharide ReceptorsLipopolysaccharidesMacrophagesSignal TransductionToll-Like Receptor 4TRPV Cation ChannelsAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutCd14 protein, mouseLipopolysaccharide ReceptorsLipopolysaccharidesTlr4 protein, mouseToll-Like Receptor 4TRPV1 protein, mouseTRPV Cation Channelsinflammationlipopolysaccharide (LPS)macrophageToll-like receptor 4 (TLR4)transient receptor potential vanilloid 1 (TRPV1)

Identifiers

PMID38508727
PMCPMC11254490

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.