Evidence map›Paper›PMID 38508719›Full record

ArticleThorax2024

Prevalence of lung cysts in adolescents and adults with a germline

Alexander T Nelson, Lauren M Vasta, Dave Watson, Jung Kim, Anne K Harris, Ana F Best, Laura A Harney, Ann G Carr, Nicole Frederickson, Louis P Dehner and 8 more

Open access · greenAbstract read
In one paragraph

Article in Thorax, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Cancers · 2025
    Review
  7. Prognostic Significance of GermlineJCO precision oncology · 2025
    Article
  8. Article
  9. Review
  10. Update on Pediatric Surveillance Recommendations for PTEN Hamartoma Tumor Syndrome, DICER1-Related Tumor Predisposition, and Tuberous Sclerosis Complex.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Review
  11. DICER1-Related Tumor Predisposition: Identification of At-risk Individuals and Recommended Surveillance Strategies.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  12. The Histological Spectrum of DICER1-Associated Neoplasms.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

Alexander T NelsonUniversity of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID 0000-0002-1611-4577
Lauren M VastaClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.ORCID 0000-0003-0208-1409
Dave WatsonResearch Institute, Children's Minnesota, Minneapolis, Minnesota, USA.
Jung KimClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Anne K HarrisInternational Pleuropulomary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, Minnesota, USA.
Ana F BestBiometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-4467-1725
Laura A HarneyWestat Inc, Rockville, Maryland, USA.ORCID 0000-0002-9223-2444
Ann G CarrWestat Inc, Rockville, Maryland, USA.
Nicole FredericksonInternational Pleuropulomary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, Minnesota, USA.
Louis P DehnerLauren V. Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA.
Christian P KratzPediatric Hematology and Oncology, Hannover Medical School, Hannover, Niedersachsen, Germany.ORCID 0000-0003-4120-5873
Kelly N HagedornDepartment of Radiology, Children's Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-6251-9359
William A MizeDepartment of Radiology, Children's Minnesota, Minneapolis, Minnesota, USA.
Alexander LingDepartment of Radiology, NIH Clinical Center, Bethesda, Maryland, USA.
Yoav H MessingerInternational Pleuropulomary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-7990-1802
D Ashley HillLauren V. Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID 0000-0003-1067-3922
Kris Ann P SchultzInternational Pleuropulomary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, Minnesota, USA krisann.schultz@childrensmn.org.ORCID 0000-0002-1788-5832
Douglas R StewartClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.ORCID 0000-0001-8193-1488
Children’s Minnesota - St. Paul Hospital · USChildren's Minnesota · USNational Cancer Institute · USWashington University in St. Louis · USWestat (United States) · USMedizinische Hochschule Hannover · DENational Institutes of Health · USNational Institutes of Health Clinical Center · US

Funding

Clinical Genetic Studies of Familial and Hereditary Cancer SyndromesZIACP010144 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$111.8M
DICER1 and the Pleuropulmonary Blastoma Family Cancer SyndromeR01CA143167 · NCI · CHILDREN'S RESEARCH INSTITUTE · PI HILL, DANA ASHLEY · 2010 to 2020
$3.7M
Detecting DICER1: A global partnership to cure pediatric lung cancerR37CA244940 · NCI · CHILDREN'S HOSPITALS AND CLINICS · PI Kris Ann Pinekenstein Schultz · 2020 to 2026
$2.4M
NCI NIH HHS R01 CA143167NCI NIH HHS R37 CA244940
6 · The paper itself

Abstract

backgroundPleuropulmonary blastoma (PPB), the hallmark tumour associated with

methodsIndividuals were enrolled in the National Cancer Institute Natural History of

resultsIn the combined databases, 110 individuals with a germline

conclusionLung cysts are common in adolescents and adults with germline

Indexed as

CystsDEAD-box RNA HelicasesGerm-Line MutationPulmonary BlastomaRegistriesRibonuclease IIIAdolescentAdultAgedChildFemaleHumansLung DiseasesLung NeoplasmsMaleMiddle AgedDEAD-box RNA HelicasesDICER1 protein, humanRibonuclease IIIImaging/CT MRI etcLung CancerPaediatric Lung DisaeseRare lung diseases

Identifiers

PMID38508719
PMCPMC11179973
OpenAlexW4392985729

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.