Evidence map›Paper›PMID 38508196›Full record

ReviewCell chemical biology2024

Chemical immunology: Recent advances in tool development and applications.

Yujie Shi, Eleanor E Bashian, Yingqin Hou, Peng Wu

Abstract readReview
In one paragraph

Review in Cell chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yujie ShiDepartment of Molecular and Cellular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Eleanor E BashianDepartment of Molecular and Cellular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Yingqin HouDepartment of Molecular and Cellular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Peng WuDepartment of Molecular and Cellular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: pengwu@scripps.edu.

Funding

Engineer Immune Cells via Chemoenzymatic Glycan EditingR01AI143884 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI TEIJARO, JOHN ROSS, WU, PENG · 2019 to 2023
$4.7M
Chemoenzymatic glycan editing for deciphering biological functions of glycansR35GM139643 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI Peng Wu · 2021 to 2026
$4.7M
Exploring Siglec-glycan ligand interactions using chemoenzymatic approachesR01AI154138 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WU, PENG · 2021 to 2025
$4.1M
NIAID NIH HHS R01 AI143884NIAID NIH HHS R01 AI154138NIGMS NIH HHS R35 GM139643
6 · The paper itself

Abstract

Immunology was one of the first biological fields to embrace chemical approaches. The development of new chemical approaches and techniques has provided immunologists with an impressive arsenal of tools to address challenges once considered insurmountable. This review focuses on advances at the interface of chemistry and immunobiology over the past two decades that have not only opened new avenues in basic immunological research, but also revolutionized drug development for the treatment of cancer and autoimmune diseases. These include chemical approaches to understand and manipulate antigen presentation and the T cell priming process, to facilitate immune cell trafficking and regulate immune cell functions, and therapeutic applications of chemical approaches to disease control and treatment.

Indexed as

antibody-drug conjugatescell traffickingchemical immunologyclick chemistryglycoimmune checkpointsimmunotherapyinnate immune responseproximity labelingsite-specific conjugationT cell priming

Identifiers

PMID38508196
PMCPMC11393185

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.