ArticleCell reports2024
Energy balance drives diurnal and nocturnal brain transcriptome rhythms.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Mating imperatives drive plasticity of the daily temporal niche in fruit flies.Nature ecology & evolution · 2026Article
- Circadian Controlled Transcription in Brain and Peripheral Organs of Juvenile and Adult Mice.International journal of molecular sciences · 2026Article
- A cellular basis for the mammalian nocturnal-diurnal switch.Science (New York, N.Y.) · 2026Article
- Spatial transcriptomics reveals brain-wide circadian disruption in an Alzheimer's disease model.bioRxiv : the preprint server for biology · 2026Article
- CCorGsDB: a database for clock correlated genes in the mouse and human central nervous systems.Npj biological timing and sleep · 2026Article
- Markers of mitochondrial function and oxidative metabolism in skeletal muscle do not display intrinsic circadian regulation in female mice.American journal of physiology. Endocrinology and metabolism · 2025Article
- Widespread temporal niche partitioning in an adaptive radiation of cichlid fishes.Nature ecology & evolution · 2025Article
- IL-6 decodes sex and diet-dependent circadian and metabolic rhythms.Molecular metabolism · 2025Article
- Molecular basis of circadian rhythm divergence between diurnal and nocturnal lepidoperans.iScience · 2025Article
- Insect circadian plasticity as a proposed target for the expression of parasite extended phenotypes.Npj biological timing and sleep · 2025Review
- Circadian Regulation in Diurnal Mammals: Neural Mechanisms and Implications in Translational Research.Biology · 2024Review
- Transcriptomic Plasticity of the Circadian Clock in Response to Photoperiod: A Study in Male Melatonin-Competent Mice.Journal of biological rhythms · 2024Article
- Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport.Cell metabolism · 2024Article
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Authors and funding
8 authors.
Funding
Abstract
Plasticity in daily timing of activity has been observed in many species, yet the underlying mechanisms driving nocturnality and diurnality are unknown. By regulating how much wheel-running activity will be rewarded with a food pellet, we can manipulate energy balance and switch mice to be nocturnal or diurnal. Here, we present the rhythmic transcriptome of 21 tissues, including 17 brain regions, sampled every 4 h over a 24-h period from nocturnal and diurnal male CBA/CaJ mice. Rhythmic gene expression across tissues comprised different sets of genes with minimal overlap between nocturnal and diurnal mice. We show that non-clock genes in the suprachiasmatic nucleus (SCN) change, and the habenula was most affected. Our results indicate that adaptive flexibility in daily timing of behavior is supported by gene expression dynamics in many tissues and brain regions, especially in the habenula, which suggests a crucial role for the observed nocturnal-diurnal switch.
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