Evidence map›Paper›PMID 38507820›Full record

ArticleJournal of medicinal chemistry2024

Novel PET Imaging Probe for Quantitative Detection of Senescence In Vivo.

Xin Xiang, Chuning Dong, Lianbo Zhou, Jun Liu, Zachary M Rabinowitz, Yuzhao Zhang, Honghui Guo, Feng He, Xingdou Chen, Yunhua Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Integrating senotherapeutics into transplantation: liver reconditioning in an aging donor pool.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Current Methodologies to Assess Cellular Senescence in Cancer.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xin XiangDepartment of Nuclear Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Chuning DongDepartment of Nuclear Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Lianbo ZhouDepartment of Nuclear Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.ORCID 0000-0001-5265-1946
Jun LiuDepartment of Medicinal Chemistry, College of Pharmacy, UF Health Science Center, University of Florida, Gainesville, Florida 32610, United States.
Zachary M RabinowitzDepartment of Medicinal Chemistry, College of Pharmacy, UF Health Science Center, University of Florida, Gainesville, Florida 32610, United States.
Yuzhao ZhangDepartment of Medicinal Chemistry, College of Pharmacy, UF Health Science Center, University of Florida, Gainesville, Florida 32610, United States.
Honghui GuoDepartment of Nuclear Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Feng HeDepartment of Nuclear Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Xingdou ChenDepartment of Nuclear Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Yunhua WangDepartment of Nuclear Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Lina CuiDepartment of Medicinal Chemistry, College of Pharmacy, UF Health Science Center, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0002-8149-5206
Xiaowei MaDepartment of Nuclear Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.ORCID 0000-0002-3062-4063

Funding

PET Probes for Senescence Detection in BrainR41AG081007 · NIA · SENOTRAC BIOTECHNOLOGY LLC · PI CUI, LINA · 2022 to 2023
$498k
NIA NIH HHS R41 AG081007
6 · The paper itself

Abstract

Real-time detection of cellular senescence remains a clinical challenge. Here, we aimed to develop a positron emission tomography (PET) imaging probe targeting senescence-associated β-galactosidase (SA-β-Gal), the most widely used biomarker of cellular senescence, and investigate its performance for real-time in vivo quantitative detection of cellular senescence. A stable PET imaging agent

Indexed as

Gallium RadioisotopesPositron-Emission TomographyCell Line, TumorDoxorubicinHeLa CellsHumansDoxorubicinGallium Radioisotopes

Identifiers

PMID38507820
PMCPMC11017977

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.