ArticleThe American journal of tropical medicine and hygiene2024
Clinical Manifestations of Dengue in Children and Adults in a Hyperendemic Region of Colombia.
Article in The American journal of tropical medicine and hygiene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Clinical manifestations and laboratory findings in patients coinfected with dengue virus and SARS-CoV-2: a systematic review.BMC infectious diseases · 2026Pooled it
- Effectiveness of antiviral, immunomodulatory and platelet-enhancing agents for treatment of dengue infection: A systematic review.Virulence · 2025Pooled it
- Dengue virus infection.Nature reviews. Disease primers · 2026Review
- Severe Dengue in Children: Pathogenesis, Early Recognition, and Evidence-Informed Management.Tropical medicine and infectious disease · 2026Review
- Pediatric Arboviral Infections in Europe: Epidemiology, Clinical Features, Diagnosis and Prevention.Viruses · 2026Review
- Acute-Phase Dengue Antibody Profiles in Pediatric Patients: Influence on Viremia and Disease Manifestations.Viruses · 2026Article
- Fulminant hepatitis secondary to dengue in pediatric patients: a series of four cases.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- Clinical profile and predictors of adverse outcomes in pediatric dengue fever presenting with febrile illness: a prospective observational study in Burao, Somaliland.Frontiers in pediatrics · 2026Article
- Sickle cell disease implicated in the development of severe dengue: A pediatric case series.Revista da Sociedade Brasileira de Medicina Tropical · 2026Article
- Early and late biomarkers as predictors of severe dengue: a comprehensive umbrella review protocol.BMJ open · 2025Article
- Dengue virus infection in children: Serum lipidomics profiling for biomarker discovery.PLoS neglected tropical diseases · 2025Article
- Using Data Mining to Differentiate Dengue with Warning Signs from Severe Dengue: A Predictive Model from Oaxaca, Mexico.The American journal of tropical medicine and hygiene · 2025Article
- Increase of Dengue in Pediatric Travelers in Madrid: A Multicentric Retrospective Experience.Tropical medicine and infectious disease · 2025Article
- Article
- Clinical and epidemiological characteristics of the dengue outbreak of 2024: a multicenter observation from Bangladesh.Tropical medicine and health · 2025Article
- Dengue in older inpatients in the post-COVID-19 Period: a case series from a North Indian tertiary center.IDCases · 2025Article
- High prevalence of dengue with warning signs but absence of severe cases in Vietnamese pediatric patients: an analysis of predictive factors.Le infezioni in medicina · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue is the most common arboviral disease in the world. Traditionally, it has affected more adults, but the incidence in children has increased in recent years. Colombia is no stranger to this change; therefore, we aimed to find the differences in signs, symptoms, and clinical, hematological, and hemogram characteristics between children under 12 years old and individuals aged 12 years and older in an endemic region of Colombia in 2020-2022. The analyses were conducted with baseline data, corresponding to a cross-sectional design. Multiple correspondence analysis was used for general, dermatological, and clinical symptom profiles. Discriminant analysis was used for laboratory profiles. Multiple correspondence analysis was applied to nominal categorical data, employing Euclidean distances to analyze age groups. Discriminant analysis was applied to a training sample and validated on a test sample. The overall agreement of the model's discrimination, sensitivity, specificity, and fit indicators was calculated. The results indicated that individuals under 12 years exhibited distinct dermatological and clinical features, including rash, pruritus, hypotension, lymphocyte count, and platelet count, compared with those aged 12 years and older. In contrast, those 12 years and older were profiled for general and clinical symptoms such as pain (back pain, retro-orbital pain, headache), dizziness, chills, hematuria, tachypnea, and elevated/high hematocrit, hemoglobin, and basophil values. These findings are crucial to understanding the high incidence in children; they also facilitate rapid understanding of the disease in clinical care settings and differentiate it from other febrile outbreaks. This will affect disease control, particularly in severe cases, and reduce mortality.
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