ArticleNeurology(R) neuroimmunology & neuroinflammation2024
Functional Signature of LRP4 Antibodies in Myasthenia Gravis.
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Article in Neurology(R) neuroimmunology & neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
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7 citing papers in PubMed, 16 citations in OpenAlex.
- Complement deposition, IgG subtyping and endplate destruction in LRP4-ab-positive myasthenia gravis.Acta neuropathologica communications · 2026Observational
- Enhanced antibody detection via live cell-based assay among RIA negative myasthenia gravis patients: toward improved diagnosis and clinical correlates.Journal of neurology · 2026Article
- The immune microenvironment and population heterogeneity in myasthenia gravis: implications for precision therapeutics.Frontiers in immunology · 2026Review
- Autoimmune Neuromuscular Disorders at a Molecular Crossroad: Linking Pathogenesis to Targeted Immunotherapy.International journal of molecular sciences · 2025Review
- Therapeutic strategies targeting complement in myasthenia gravis patients.Journal of neurology · 2025Review
- Review
- Myasthenia gravis: the future is here.The Journal of clinical investigation · 2024Review
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Authors and funding
11 authors at 1 institution in 1 country.
Omar ChuquisanaFrom the Department of Neurology with Institute of Translational Neurology (O.C., C.W.K., H.W., J.D.L.), University Hospital Münster; Department of Neurology with Experimental Neurology (F.S., A.M.); Neuroscience Clinical Research Center (F.S., A.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany; Genos Glycoscience Research Laboratory (M.P.-B., A.-M.P., G.L.), Zagreb; Faculty of Pharmacy and Biochemistry (G.L.), University of Zagreb, Croatia; Tzartos NeuroDiagnostics (S.T.); Department of Neurobiology (S.T.), Hellenic Pasteur Institute, Athens, Greece; Nuffield Department of Clinical Neurosciences (N.W.), Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom; and Center for Stroke Research Berlin (A.G.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany.
Frauke StascheitFrom the Department of Neurology with Institute of Translational Neurology (O.C., C.W.K., H.W., J.D.L.), University Hospital Münster; Department of Neurology with Experimental Neurology (F.S., A.M.); Neuroscience Clinical Research Center (F.S., A.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany; Genos Glycoscience Research Laboratory (M.P.-B., A.-M.P., G.L.), Zagreb; Faculty of Pharmacy and Biochemistry (G.L.), University of Zagreb, Croatia; Tzartos NeuroDiagnostics (S.T.); Department of Neurobiology (S.T.), Hellenic Pasteur Institute, Athens, Greece; Nuffield Department of Clinical Neurosciences (N.W.), Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom; and Center for Stroke Research Berlin (A.G.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany.ORCID 0000-0001-5306-7880
Christian W KellerFrom the Department of Neurology with Institute of Translational Neurology (O.C., C.W.K., H.W., J.D.L.), University Hospital Münster; Department of Neurology with Experimental Neurology (F.S., A.M.); Neuroscience Clinical Research Center (F.S., A.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany; Genos Glycoscience Research Laboratory (M.P.-B., A.-M.P., G.L.), Zagreb; Faculty of Pharmacy and Biochemistry (G.L.), University of Zagreb, Croatia; Tzartos NeuroDiagnostics (S.T.); Department of Neurobiology (S.T.), Hellenic Pasteur Institute, Athens, Greece; Nuffield Department of Clinical Neurosciences (N.W.), Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom; and Center for Stroke Research Berlin (A.G.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany.
Maja Pučić-BakovićFrom the Department of Neurology with Institute of Translational Neurology (O.C., C.W.K., H.W., J.D.L.), University Hospital Münster; Department of Neurology with Experimental Neurology (F.S., A.M.); Neuroscience Clinical Research Center (F.S., A.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany; Genos Glycoscience Research Laboratory (M.P.-B., A.-M.P., G.L.), Zagreb; Faculty of Pharmacy and Biochemistry (G.L.), University of Zagreb, Croatia; Tzartos NeuroDiagnostics (S.T.); Department of Neurobiology (S.T.), Hellenic Pasteur Institute, Athens, Greece; Nuffield Department of Clinical Neurosciences (N.W.), Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom; and Center for Stroke Research Berlin (A.G.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany.
Anne-Marie PatenaudeFrom the Department of Neurology with Institute of Translational Neurology (O.C., C.W.K., H.W., J.D.L.), University Hospital Münster; Department of Neurology with Experimental Neurology (F.S., A.M.); Neuroscience Clinical Research Center (F.S., A.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany; Genos Glycoscience Research Laboratory (M.P.-B., A.-M.P., G.L.), Zagreb; Faculty of Pharmacy and Biochemistry (G.L.), University of Zagreb, Croatia; Tzartos NeuroDiagnostics (S.T.); Department of Neurobiology (S.T.), Hellenic Pasteur Institute, Athens, Greece; Nuffield Department of Clinical Neurosciences (N.W.), Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom; and Center for Stroke Research Berlin (A.G.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany.
Gordan LaucFrom the Department of Neurology with Institute of Translational Neurology (O.C., C.W.K., H.W., J.D.L.), University Hospital Münster; Department of Neurology with Experimental Neurology (F.S., A.M.); Neuroscience Clinical Research Center (F.S., A.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany; Genos Glycoscience Research Laboratory (M.P.-B., A.-M.P., G.L.), Zagreb; Faculty of Pharmacy and Biochemistry (G.L.), University of Zagreb, Croatia; Tzartos NeuroDiagnostics (S.T.); Department of Neurobiology (S.T.), Hellenic Pasteur Institute, Athens, Greece; Nuffield Department of Clinical Neurosciences (N.W.), Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom; and Center for Stroke Research Berlin (A.G.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany.
Socrates TzartosFrom the Department of Neurology with Institute of Translational Neurology (O.C., C.W.K., H.W., J.D.L.), University Hospital Münster; Department of Neurology with Experimental Neurology (F.S., A.M.); Neuroscience Clinical Research Center (F.S., A.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany; Genos Glycoscience Research Laboratory (M.P.-B., A.-M.P., G.L.), Zagreb; Faculty of Pharmacy and Biochemistry (G.L.), University of Zagreb, Croatia; Tzartos NeuroDiagnostics (S.T.); Department of Neurobiology (S.T.), Hellenic Pasteur Institute, Athens, Greece; Nuffield Department of Clinical Neurosciences (N.W.), Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom; and Center for Stroke Research Berlin (A.G.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany.
Heinz WiendlFrom the Department of Neurology with Institute of Translational Neurology (O.C., C.W.K., H.W., J.D.L.), University Hospital Münster; Department of Neurology with Experimental Neurology (F.S., A.M.); Neuroscience Clinical Research Center (F.S., A.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany; Genos Glycoscience Research Laboratory (M.P.-B., A.-M.P., G.L.), Zagreb; Faculty of Pharmacy and Biochemistry (G.L.), University of Zagreb, Croatia; Tzartos NeuroDiagnostics (S.T.); Department of Neurobiology (S.T.), Hellenic Pasteur Institute, Athens, Greece; Nuffield Department of Clinical Neurosciences (N.W.), Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom; and Center for Stroke Research Berlin (A.G.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany.ORCID 0000-0003-4310-3432
Nick WillcoxFrom the Department of Neurology with Institute of Translational Neurology (O.C., C.W.K., H.W., J.D.L.), University Hospital Münster; Department of Neurology with Experimental Neurology (F.S., A.M.); Neuroscience Clinical Research Center (F.S., A.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany; Genos Glycoscience Research Laboratory (M.P.-B., A.-M.P., G.L.), Zagreb; Faculty of Pharmacy and Biochemistry (G.L.), University of Zagreb, Croatia; Tzartos NeuroDiagnostics (S.T.); Department of Neurobiology (S.T.), Hellenic Pasteur Institute, Athens, Greece; Nuffield Department of Clinical Neurosciences (N.W.), Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom; and Center for Stroke Research Berlin (A.G.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany.
Andreas MeiselFrom the Department of Neurology with Institute of Translational Neurology (O.C., C.W.K., H.W., J.D.L.), University Hospital Münster; Department of Neurology with Experimental Neurology (F.S., A.M.); Neuroscience Clinical Research Center (F.S., A.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany; Genos Glycoscience Research Laboratory (M.P.-B., A.-M.P., G.L.), Zagreb; Faculty of Pharmacy and Biochemistry (G.L.), University of Zagreb, Croatia; Tzartos NeuroDiagnostics (S.T.); Department of Neurobiology (S.T.), Hellenic Pasteur Institute, Athens, Greece; Nuffield Department of Clinical Neurosciences (N.W.), Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom; and Center for Stroke Research Berlin (A.G.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany.ORCID 0000-0001-7233-5342
Jan D LünemannFrom the Department of Neurology with Institute of Translational Neurology (O.C., C.W.K., H.W., J.D.L.), University Hospital Münster; Department of Neurology with Experimental Neurology (F.S., A.M.); Neuroscience Clinical Research Center (F.S., A.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany; Genos Glycoscience Research Laboratory (M.P.-B., A.-M.P., G.L.), Zagreb; Faculty of Pharmacy and Biochemistry (G.L.), University of Zagreb, Croatia; Tzartos NeuroDiagnostics (S.T.); Department of Neurobiology (S.T.), Hellenic Pasteur Institute, Athens, Greece; Nuffield Department of Clinical Neurosciences (N.W.), Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom; and Center for Stroke Research Berlin (A.G.M.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany.ORCID 0000-0002-3007-708X
Humboldt-Universität zu Berlin · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesAntibodies (Abs) specific for the low-density lipoprotein receptor-related protein 4 (LRP4) occur in up to 5% of patients with myasthenia gravis (MG). The objective of this study was to profile LRP4-Ab effector actions.
methodsWe evaluated the efficacy of LRP4-specific compared with AChR-specific IgG to induce Ab-dependent cellular phagocytosis (ADCP), Ab-dependent cellular cytotoxicity (ADCC), and Ab-dependent complement deposition (ADCD). Functional features were additionally assessed in an independent AChR-Ab
resultsEffector actions that required binding of Fc domains to cellular FcRs such as ADCC and ADCP were detectable for both LRP4-specific and AChR-specific Abs. In contrast to AChR-Abs, LRP4-binding Abs showed poor efficacy in inducing complement deposition. Levels of circulating activated complement proteins were not substantially increased in LRP4-Ab-positive MG. Frequency of IgG glycovariants carrying 2 sialic acid residues, indicative for anti-inflammatory IgG activity, was decreased in patients with LRP4-Ab-positive MG. DISCUSSION: LRP4-Abs are more effective in inducing cellular FcR-mediated effector mechanisms than Ab-dependent complement activation. Their functional signature is different from AChR-specific Abs.
Indexed as
Myasthenia GravisReceptors, CholinergicAutoantibodiesComplement System ProteinsHumansImmunoglobulin GLDL-Receptor Related ProteinsReceptor Protein-Tyrosine KinasesAutoantibodiesComplement System ProteinsImmunoglobulin GLDL-Receptor Related ProteinsLRP4 protein, humanReceptor Protein-Tyrosine KinasesReceptors, Cholinergic
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