Evidence map›Paper›PMID 38507125›Full record

ArticleDigestive diseases and sciences2024

Highly Expressed Z-DNA Binding Protein 1 in Esophageal Cancer Promotes Tumor Growth.

Shabahaiti Wusiman, Yining Liu, Hui Li, Yuhan Deng, Ximing Qu, Hainisayimu Tuerxun, Ling Liu

Abstract read
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Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Formation and biological implications of Z-DNA.Trends in genetics : TIG · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shabahaiti WusimanDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xinjiang Medical University, Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China.
Yining LiuLaboratory Department, The Third People's Hospital of Xinjiang, Urumqi, Xinjiang Uygur Autonomous Region, China.
Hui LiCentral Laboratory of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China.
Yuhan DengDepartment of Thoracic Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China.
Ximing QuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xinjiang Medical University, Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China.
Hainisayimu TuerxunDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xinjiang Medical University, Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China.
Ling LiuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xinjiang Medical University, Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China. liulingpine@126.com.ORCID http://orcid.org/0000-0002-8688-2184

Funding

Special Research Project for Health and Young Medical Science and Technology Talents in Xinjiang Uygur Autonomous Region WJWY-202345
6 · The paper itself

Abstract

backgroundEsophageal cancer (ESCA) is a common malignant tumor of the digestive tract, and its poor prognosis is mainly attributed to the occurrence of invasion and metastasis. Z-DNA binding protein 1 (ZBP1), as a mRNA regulatory factor, plays an important role in the occurrence and development of various tumors. However, the role of ZBP1 in ESCA is not yet understood.

aimsThis study aims to explore the expression of ZBP1 in ESCA and its role in the development of ESCA.

methodsUsing bioinformatics analysis and immunohistochemistry staining, we detected the expression of ZBP1 in ESCA and normal tissues. The potential mechanism of ZBP1 in ESCA was analyzed from the aspects of genetic mutations, protein interaction networks, and pathway enrichment. We performed functional experiments in vitro to elucidate the effect of ZBP1 on ESCA cells.

resultsZBP1 was found to be significantly upregulated in ESCA compared to adjacent noncancerous tissues, and its expression is closely related to gender, age, and lymph node metastasis. In ESCA, the genetic variation rate of ZBP1 is 8%, and its expression is positively correlated with immune cell infiltration. The ZBP1 co-expressed gene is mainly involved in processes such as lymph node proliferation and intercellular adhesion. In vitro experiments have confirmed that downregulation of ZBP1 significantly inhibited the proliferation, migration, and invasion of ESCA cells.

conclusionThis research proves that downregulation of ZBP1 can inhibit the progression of ESCA. This finding indicates that ZBP1 may be a novel biomarker to improve the diagnosis and treatment of ESCA.

Indexed as

Esophageal NeoplasmsRNA-Binding ProteinsCell Line, TumorCell ProliferationDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticHumansLymphatic MetastasisMaleUp-RegulationDNA-Binding ProteinsRNA-Binding ProteinsZBP1 protein, humanBioinformatics analysisEsophageal cancerInvasionMigrationZBP1

Identifiers

PMID38507125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.