ArticleActa diabetologica2024
Associations of muscle mass and strength with new-onset diabetes among middle-aged and older adults: evidence from the China health and retirement longitudinal study (CHARLS).
Article in Acta diabetologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical importance of simple muscular fitness tests to predict long-term health conditions: a systematic review and meta-analysis of 94 cohort studies.British journal of sports medicine · 2026Pooled it
- Associations between sarcopenic obesity and the risk of cardiovascular-kidney-metabolic syndrome progression: insights from the China health and retirement longitudinal study.Diabetology & metabolic syndrome · 2025Article
- Physical performance outweighs grip strength in predicting diabetes risk: evidence from a prospective cohort study.Journal of translational medicine · 2025Article
- Association between relative muscle strength and cardiometabolic multimorbidity in middle-aged and older Chinese adults.Acta diabetologica · 2025Article
- Association between lipid accumulation products and relative handgrip strength: a large population-based study.Scientific reports · 2025Article
- Association of serum creatinine/cystatin C ratio with insulin resistance and all-cause mortality: a national cohort analysis.Frontiers in nutrition · 2025Article
- Whole-body vibration training improves muscle mass and strength in older adults through intra- and extra-muscular pathways.Frontiers in cell and developmental biology · 2025Review
- Low muscle mass is associated with low insulin sensitivity, impaired pancreatic β cell function, and high glucose excursion in nondiabetic nonobese Japanese women.Metabolism open · 2024Article
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Authors and funding
4 authors.
Funding
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Abstract
backgroundThe associations of muscle mass and strength with new-onset Type 2 diabetes mellitus (T2DM) remain controversial. We aimed to longitudinally evaluate muscle mass and strength in predicting T2DM among Chinese middle-aged and older adults.
methodsWe enrolled 6033 participants aged ≥ 45 years from the China Health and Retirement Longitudinal Study (CHARLS), a cohort survey, between 2011 and 2012. The appendicular skeletal muscle mass (normalized by weight, ASM/BW%), relative hand grip strength (normalized by weight, HGS/BW), and five-repetition chair stand test (5CST). were all categorized into tertiles (lowest, middle, and highest groups) at baseline, respectively. Individuals were followed up until the occurrence of diabetes or the end of CHARLS 2018, whichever happened first. Cox proportional hazards models to calculate hazard ratios with 95% confidence intervals (CI) and mediation analysis were used.
resultsDuring follow-up, 815 (13.5%) participants developed T2DM. After adjusting for covariates, lower ASW/BW% was not associated with a higher risk of diabetes. Compared with individuals in the highest tertile of HGS/BW, those in the lowest tertile had 1.296 (95%CI 1.073-1.567) higher risk of diabetes. Compared with individuals in the lowest tertile of 5CST, those in the highest tertile had 1.329 times (95%CI 1.106-1.596) higher risk of diabetes. By subgroup, both the lowest HGS/BW and highest 5CST were risk factors for diabetes among obesity. The mediation analysis revealed that the effect of HGS/BW on the risk of diabetes is mainly mediated by insulin resistance.
conclusionsLower muscle strength is associated with an increased risk of diabetes, especially in obese populations.
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