Evidence map›Paper›PMID 38507081›Full record

ReviewNeuroradiology2024

Autoimmune encephalitis: what the radiologist needs to know.

Francesco Sanvito, Anna Pichiecchio, Matteo Paoletti, Giacomo Rebella, Martina Resaz, Luana Benedetti, Federico Massa, Silvia Morbelli, Eduardo Caverzasi, Carlo Asteggiano and 6 more

Abstract readReview
In one paragraph

Review in Neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Persistent Bilateral [Annals of clinical and translational neurology · 2026
    Article
  6. Journal of neurology · 2026
    Article
  7. Article
  8. Article
  9. Multimodal temporal dissociation in anti-GABAFrontiers in immunology · 2026
    Article
  10. Novel Magnetic Resonance Imaging Findings of Bilaterally Symmetrical Lesions in a Dog With Concomitant Granulomatous Meningoencephalitis and Necrotizing Encephalitis.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026
    Article
  11. The first reported case ofFrontiers in medicine · 2026
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Managing paraneoplastic GABABMC neurology · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Francesco SanvitoUnit of Radiology, Department of Clinical, Surgical, Diagnostic, and Paediatric Sciences, University of Pavia, Viale Camillo Golgi, 19, 27100, Pavia, Italy. francesco.sanvito01@universitadipavia.it.ORCID http://orcid.org/0000-0003-3379-9958
Anna PichiecchioDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Matteo PaolettiAdvanced Imaging and Artificial Intelligence Center, Department of Neuroradiology, IRCCS Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy.
Giacomo RebellaIRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy.
Martina ResazIRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy.
Luana BenedettiIRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy.
Federico MassaIRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy.
Silvia MorbelliIRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy.
Eduardo CaverzasiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Carlo AsteggianoAdvanced Imaging and Artificial Intelligence Center, Department of Neuroradiology, IRCCS Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy.
Pietro BusinaroDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Stefano MasciocchiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Lucio CastellanIRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy.
Diego FranciottaNeuroimmunology Laboratory and Neuroimmunology Research Section, IRCCS Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy.
Matteo GastaldiNeuroimmunology Laboratory and Neuroimmunology Research Section, IRCCS Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy.
Luca RoccatagliataIRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy.

Funding

Ministero della Salute Ricerca Corrente 2022-2024
6 · The paper itself

Abstract

Autoimmune encephalitis is a relatively novel nosological entity characterized by an immune-mediated damage of the central nervous system. While originally described as a paraneoplastic inflammatory phenomenon affecting limbic structures, numerous instances of non-paraneoplastic pathogenesis, as well as extra-limbic involvement, have been characterized. Given the wide spectrum of insidious clinical presentations ranging from cognitive impairment to psychiatric symptoms or seizures, it is crucial to raise awareness about this disease category. In fact, an early diagnosis can be dramatically beneficial for the prognosis both to achieve an early therapeutic intervention and to detect a potential underlying malignancy. In this scenario, the radiologist can be the first to pose the hypothesis of autoimmune encephalitis and refer the patient to a comprehensive diagnostic work-up - including clinical, serological, and neurophysiological assessments.In this article, we illustrate the main radiological characteristics of autoimmune encephalitis and its subtypes, including the typical limbic presentation, the features of extra-limbic involvement, and also peculiar imaging findings. In addition, we review the most relevant alternative diagnoses that should be considered, ranging from other encephalitides to neoplasms, vascular conditions, and post-seizure alterations. Finally, we discuss the most appropriate imaging diagnostic work-up, also proposing a suggested MRI protocol.

Indexed as

Autoimmune Diseases of the Nervous SystemEncephalitisHashimoto DiseaseLimbic EncephalitisAutoantibodiesHumansRadiologistsSeizuresAutoantibodiesAutoimmune diseases of the nervous systemAutoimmune encephalitisEncephalitisLimbic encephalitisMagnetic resonance imaging

Identifiers

PMID38507081
PMCPMC11031487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.