Evidence map›Paper›PMID 38507046›Full record

ReviewGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2024

The hypothetical molecular mechanism of the ethnic variations in the manifestation of age-related macular degeneration; focuses on the functions of the most significant susceptibility genes.

Shigeru Honda, Norihiko Misawa, Yusuke Sato, Daisuke Oikawa, Fuminori Tokunaga

Abstract readReview
PubMed Publisher
In one paragraph

Review in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shigeru HondaDepartment of Ophthalmology and Visual Sciences, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahi-Machi, Abeno-Ku, Osaka, Japan. shonda@omu.ac.jp.ORCID http://orcid.org/0000-0002-0632-997X
Norihiko MisawaDepartment of Ophthalmology and Visual Sciences, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahi-Machi, Abeno-Ku, Osaka, Japan.
Yusuke SatoCenter for Research On Green Sustainable Chemistry, Graduate School of Engineering, Tottori University, Tottori, Japan.
Daisuke OikawaDepartment of Medical Biochemistry, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Fuminori TokunagaDepartment of Medical Biochemistry, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.

Funding

Ministry of Education, Culture, Sports, Science and Technology 22K09773
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is the leading sight-threatening disease in developed countries. On the other hand, recent studies indicated an ethnic variation in the phenotype of AMD. For example, several reports demonstrated that the incidence of drusen in AMD patients is less in Asians compared to Caucasians though the reason has not been clarified yet. In the last decades, several genome association studies have disclosed many susceptible genes of AMD and revealed that the association strength of some genes was different among races and AMD phenotypes. In this review article, the essential findings of the clinical studies and genome association studies for the most significant genes CFH and ARMS2/HTRA1 in AMD of different races are summarized, and theoretical hypotheses about the molecular mechanisms underlying the ethnic variation in the AMD manifestation mainly focused on those genes between Caucasians and Asians are discussed.

Indexed as

Genetic Predisposition to DiseaseMacular DegenerationAsian PeopleComplement Factor HEthnicityGenome-Wide Association StudyHigh-Temperature Requirement A Serine Peptidase 1HumansPhenotypePolymorphism, Single NucleotideProteinsWhite PeopleARMS2 protein, humanCFH protein, humanComplement Factor HHigh-Temperature Requirement A Serine Peptidase 1HTRA1 protein, humanProteinsAge-related macular degenerationEthnic variationMolecular mechanismSusceptibility gene

Identifiers

PMID38507046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.