Evidence map›Paper›PMID 38506981›Full record

ArticleClinical and experimental nephrology2024

Kidney damage relates to agonal bacteremia: a single-center retrospective study.

Yumiko Mikami, Meiko Ogawa, Yuuki Hayasaka, Asuka Yamakami, Kanako Hattori, Chizumi Fukazawa, Takafumi Ito, Naoki Kanomata, Hiroyuki Terawaki

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Article in Clinical and experimental nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yumiko MikamiClinical Laboratory Department, St. Luke's International University, 9-1 Akashi-Cho, Chuo-City, Tokyo, Japan.
Meiko OgawaDepartment of Pathology, St. Luke's International Hospital, Tokyo, Japan.
Yuuki HayasakaClinical Laboratory Department, St. Luke's International University, 9-1 Akashi-Cho, Chuo-City, Tokyo, Japan.
Asuka YamakamiClinical Laboratory Department, St. Luke's International University, 9-1 Akashi-Cho, Chuo-City, Tokyo, Japan.
Kanako HattoriClinical Laboratory Department, St. Luke's International University, 9-1 Akashi-Cho, Chuo-City, Tokyo, Japan.
Chizumi FukazawaClinical Laboratory Department, St. Luke's International University, 9-1 Akashi-Cho, Chuo-City, Tokyo, Japan.
Takafumi ItoDepartment of Nephrology, Teikyo University Chiba Medical Hospital, Chiba, Japan.
Naoki KanomataDepartment of Pathology, St. Luke's International Hospital, Tokyo, Japan.
Hiroyuki TerawakiClinical Laboratory Department, St. Luke's International University, 9-1 Akashi-Cho, Chuo-City, Tokyo, Japan. terawaki@med.teikyo-u.ac.jp.ORCID http://orcid.org/0000-0001-9165-551X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAgonal bacteremia, diagnosed with postmortem positive blood culture results, is considered a possible contributing factor to death. We hypothesized that some premortem organ damage, such as kidney damage, can enhance agonal bacteremia.

methodsWe performed a postmortem blood and alveolar fluid culture study in 30 cadavers and evaluated the relationship between blood culture results and clinical parameters, including organ damage (brain, heart, lung, kidney, liver and gastrointestinal tract).

resultsA total of 23 cases (76.7%) were positive for blood culture; the number of cultured species was one in 12 cases, two in 7 cases, and three in 4 cases. The ratio of agonal bacteremia was significantly higher in patients with heart damage (100%, n = 13) and those with kidney damage (end-stage kidney damage, acute kidney injury, obstructive kidney failure, or metastatic kidney tumours) (100%, n = 13). The mean number of cultured species was 0.67 ± 0.98 in heart or kidney damage, 1.40 ± 0.55 in heart damage only, 1.40 ± 0.55 in kidney damage only, and 2.00 ± 0.93 in heart and kidney damage. As the number of damaged organs increased (0 organs, no heart/kidney damage; 1 organ, heart or kidney damage; and 2 organs, heart and kidney damage), the mean number of cultured species increased significantly (p for trend = 0.001964).

conclusionPremortem kidney damage relates to agonal bacteremia.

Indexed as

BacteremiaAdultAgedAged, 80 and overBlood CultureCadaverFemaleHumansKidneyKidney DiseasesMaleMiddle AgedRetrospective StudiesAgonal bacteremiaAutopsyChronic kidney diseaseHeart failureMALDI-TOF

Identifiers

PMID38506981

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