Evidence map›Paper›PMID 38506902›Full record

ArticleeLife2024

Inhibition of

Martin Wohlwend, Pirkka-Pekka Laurila, Ludger J E Goeminne, Tanes Lima, Ioanna Daskalaki, Xiaoxu Li, Giacomo von Alvensleben, Barbara Crisol, Renata Mangione, Hector Gallart-Ayala and 7 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  8. Article
  9. Article
  10. Nutrients · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Martin WohlwendLaboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0001-9851-0364
Pirkka-Pekka LaurilaLaboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Ludger J E GoeminneLaboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Tanes LimaLaboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Ioanna DaskalakiLaboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Xiaoxu LiLaboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0001-5121-9190
Giacomo von AlvenslebenLaboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0001-7231-0276
Barbara CrisolLaboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Renata MangioneLaboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Hector Gallart-AyalaMetabolomics Platform, Faculty of Biology and Medicine, University of Lausanne (UNIL), Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-2333-0646
Amélia LalouLaboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Olivier BurriBioimaging and optics platform, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Stephen ButlerSchool of Chemistry, University of New South Wales Sydney, Sydney, Australia.
Jonathan MorrisSchool of Chemistry, University of New South Wales Sydney, Sydney, Australia.ORCID https://orcid.org/0000-0002-5109-9069
Nigel TurnerCellular Bioenergetics Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, Australia.
Julijana IvanisevicMetabolomics Platform, Faculty of Biology and Medicine, University of Lausanne (UNIL), Lausanne, Switzerland.
Johan AuwerxLaboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-5065-5393
École Polytechnique Fédérale de Lausanne · CHUniversity of Lausanne · CHUNSW Sydney · AUVictor Chang Cardiac Research Institute · AU

Funding

European Research Council ERC-AdG-787702Swiss National Science Foundation 31003A_179435
6 · The paper itself

Abstract

Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in the pathogenesis of age-related skeletal muscle impairment. In humans,

Indexed as

Muscle Fibers, SkeletalMuscle, SkeletalAgedAgingAnimalsCaenorhabditis elegansHumansMiceSphingolipidsSphingolipidsagingC. eleganscell biologyceramidegeneticshumanmousemyogenesisskeletal musclesphingolipid

Identifiers

PMID38506902
PMCPMC10954306
OpenAlexW4387140744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.