Evidence map›Paper›PMID 38506634›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

The Abca7

Claire A Butler, Adrian Mendoza Arvilla, Giedre Milinkeviciute, Celia Da Cunha, Shimako Kawauchi, Narges Rezaie, Heidi Y Liang, Dominic Javonillo, Annie Thach, Shuling Wang and 13 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Abi3Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Microglial phagocytosis in Alzheimer disease.Nature reviews. Neurology · 2026
    Review
  4. Article
  5. Amyloid-Related Imaging Abnormality (ARIA) Beyond the APOE-ε4 Allele.Chronic diseases and translational medicine · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. The Abca7Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 2 institutions in 1 country.

Claire A ButlerDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Adrian Mendoza ArvillaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Giedre MilinkeviciuteInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Celia Da CunhaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Shimako KawauchiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Narges RezaieDepartment of Developmental and Cell Biology, University of California, Irvine, California, USA.
Heidi Y LiangDepartment of Developmental and Cell Biology, University of California, Irvine, California, USA.
Dominic JavonilloDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Annie ThachInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Shuling WangTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Sherilyn CollinsTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Amber WalkerTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Kai-Xuan ShiTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Jonathan NeumannTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Angela Gomez-ArboledasInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Caden M HenningfieldDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Lindsay A HohsfieldDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Mark MapstoneInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Andrea J TennerDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Frank M LaFerlaDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Ali MortazaviDepartment of Developmental and Cell Biology, University of California, Irvine, California, USA.
Grant R MacGregorTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Kim N GreenDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
University of California, Irvine · USIrvine University · US

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Craig E Stark · 2017 to 2026
$71.9M
Cancer Center Support CA-62203Center for Complex Biological Systems Support GM-076516NIA NIH HHS U54 AG054349
6 · The paper itself

Abstract

backgroundVariants in ABCA7, a member of the ABC transporter superfamily, have been associated with increased risk for developing late onset Alzheimer's disease (LOAD).

methodsCRISPR-Cas9 was used to generate an Abca7

resultsAbca7 DISCUSSION: Overall, homozygosity for the Abca7 HIGHLIGHTS: ABCA7 recognized as a top 10 risk gene for developing Alzheimer's disease. Loss of function mutations result in increased risk for LOAD. V1613M variant reduces amyloid beta plaque burden in 5xFAD mice. V1613M variant modulates APP processing and trafficking in 5xFAD mice. V1613M variant reduces amyloid beta-associated damage in 5xFAD mice.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesATP-Binding Cassette TransportersMice, TransgenicPlaque, AmyloidAmyloid beta-Protein PrecursorAnimalsBrainDisease Models, AnimalHumansMiceMicrogliaNeuronsPhagocytosisABCA7 protein, humanAbca7 protein, mouseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorATP-Binding Cassette TransportersABCA7Alzheimer's diseaseAβlipidsneuroinflammation

Identifiers

PMID38506634
PMCPMC11247689
OpenAlexW4392990743

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.