Evidence map›Paper›PMID 38506589›Full record

ArticleChemistryOpen2024

Synthesis,Antidiabetic and Antitubercular Evaluation of Quinoline-pyrazolopyrimidine hybrids and Quinoline-4-Arylamines.

Nosipho Cele, Paul Awolade, Pule Seboletswe, Lungisani Khubone, Kolawole Olofinsan, Md Shahidul Islam, Audrey Jordaan, Digby F Warner, Parvesh Singh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nosipho CeleSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, South Africa.
Paul AwoladeSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, South Africa.
Pule SeboletsweSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, South Africa.
Lungisani KhuboneSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, South Africa.
Kolawole OlofinsanDepartment of Biochemistry, School of Life Sciences, University of Kwazulu-Natal, Westville, Durban, South Africa.
Md Shahidul IslamDepartment of Biochemistry, School of Life Sciences, University of Kwazulu-Natal, Westville, Durban, South Africa.
Audrey JordaanMolecular Mycobacteriology Research Unit, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa.
Digby F WarnerMolecular Mycobacteriology Research Unit, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa.
Parvesh SinghSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, South Africa.ORCID 0000-0001-6742-6389
University of KwaZulu-Natal · ZAUniversity of Cape Town · ZA

Funding

National Research Foundation (SA) SRUG2204092857
6 · The paper itself

Abstract

Two libraries of quinoline-based hybrids 1-(7-chloroquinolin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine and 7-chloro-N-phenylquinolin-4-amine were synthesized and evaluated for their α-glucosidase inhibitory and antioxidant properties. Compounds with 4-methylpiperidine and para-trifluoromethoxy groups, respectively, showed the most promising α-glucosidase inhibition activity with IC

Indexed as

Antitubercular AgentsGlycoside Hydrolase InhibitorsHypoglycemic AgentsMolecular Docking SimulationPyrazolesPyrimidinesQuinolinesalpha-GlucosidasesAntioxidantsHumansMycobacterium tuberculosisStructure-Activity Relationshipalpha-GlucosidasesAntioxidantsAntitubercular AgentsGlycoside Hydrolase InhibitorsHypoglycemic AgentsPyrazolesPyrimidinesQuinolinesantitubercular propertiesfree radical scavengerspyrazolopyrimidinequinoline hybridsα-glucosidase inhibitors

Identifiers

PMID38506589
PMCPMC11633360
OpenAlexW4392993538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.