Evidence map›Paper›PMID 38506312›Full record

Observational studyPharmacogenomics2024

Genetic risk factors for drug-induced long QT syndrome: findings from a large real-world case-control study.

Ana I Lopez-Medina, Alessandra M Campos-Staffico, Choudhary Anwar A Chahal, Isabella Volkers, Juliet P Jacoby, Omer Berenfeld, Jasmine A Luzum

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Pharmacogenomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ana I Lopez-MedinaDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.ORCID 0000-0003-4307-7158
Alessandra M Campos-StafficoDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.ORCID 0000-0003-4172-7524
Choudhary Anwar A ChahalCenter for Inherited Cardiovascular Diseases, WellSpan Health, Lancaster, PA, USA.ORCID 0000-0001-7825-8827
Isabella VolkersDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
Juliet P JacobyDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
Omer BerenfeldCenter for Arrhythmia Research, Departments of Internal Medicine - Cardiology, Biomedical Engineering, & Applied Physics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-9532-7871
Jasmine A LuzumDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.ORCID 0000-0003-3639-717X
University of Michigan · USBritish Heart Foundation · GB

Funding

Electrical Activity Patterns in Onset and Cessation of Atrial FibrillationR01HL156961 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERENFELD, OMER · 2022 to 2025
$2.4M
CTSA Predoctoral T32 at the University of MichiganT32TR004371 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VICKI L ELLINGROD, MICHAEL Allan HOLINSTAT · 2023 to 2026
$2.2M
Precision Medicine for Heart Failure: The Role of Genomics in the Efficacy and Racial Disparity of Cornerstone PharmacotherapyK08HL146990 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUZUM, JASMINE A · 2019 to 2023
$772k
Extracorporeal and Endoscopic SWIR Mapping of Dynamic Muscle FunctionR21EB032661 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANUMONWO, JUSTUS M, BERENFELD, OMER · 2022 to 2023
$401k
Hyperspectral Mapping of Cardiac Excitation and Contraction DynamicsR21HL153694 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANUMONWO, JUSTUS M, BERENFELD, OMER · 2020 to 2021
$401k
Bleeding on Direct Oral Anticoagulants: Identification of Genetic Risk Factors and a Polygenic Predictive Score in Patients with Atrial FibrillationF32HL162231 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAMPOS STAFFICO, ALESSANDRA MENEZES · 2022 to 2022
$79k
CSR NIH HHS F32 HL162231, K08 HL146990, R01-HL156961, R21-EB032661, R21-HL153694, T32 TR004371NCATS NIH HHS T32 TR004371NHLBI NIH HHS F32 HL162231NHLBI NIH HHS K08 HL146990NHLBI NIH HHS R01 HL156961NHLBI NIH HHS R21 HL153694NIBIB NIH HHS R21 EB032661
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Long QT SyndromePotassium Channels, Voltage-GatedCase-Control StudiesHumansRisk FactorsPotassium Channels, Voltage-Gatedarrhythmiadrug-induced long QT syndromeKCNE1-D85Npharmacogenomicstorsade de pointes

Identifiers

PMID38506312
PMCPMC10964839
OpenAlexW4393003752

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.