ArticleThe Journal of clinical endocrinology and metabolism2024
Time Trends in Liver-Related Mortality in People With and Without Diabetes: Results From a Population-Based Study.
Article in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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- Time Trends in Liver-Related Mortality in People With and Without Diabetes: Results From a Population-Based Study.The Journal of clinical endocrinology and metabolism · 2024Article
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6 authors.
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Abstract
contextPatients with diabetes are at increased risk of dying from liver-related events, but little is known on whether this increased risk has changed in recent years.
objectiveThe aim of the present study is to describe time trends in cause-specific liver-related mortality in people with and without diabetes from the general Italian population.
methodsData were retrieved from the health care utilization databases of Lombardy, a region of Italy that accounts for about 16% (almost 10 million) of its population. Annual cause-specific mortality rates and proportionate mortality were computed among individuals with and without diabetes from 2010 to 2019. Liver-related deaths were categorized as viral, alcohol related, and nonviral nonalcohol related (NVNA).
resultsLiver diseases were responsible for 2% and 1% of deaths in people with and without diabetes (2019). Among patients with diabetes, the crude mortality rate for liver diseases decreased from 1.13 to 0.64 deaths per 1000 person-years from 2010 to 2019. The largest proportion of liver-related deaths was attributable to NVNA diseases and it increased from 63% in 2010 to 68% in 2019, with a corresponding relative reduction of viral causes (from 27% to 23%). The standardized mortality ratio for patients with diabetes was 3.35 (95% CI 2.96-3.76) for NVNA, 1.66 (95% CI 1.33-2.01) for viral hepatitis, and 1.61 (95% CI 1.13-2.17) for alcoholic liver disease and it remained relatively stable over time. Excess mortality risk in patients with diabetes for liver-related mortality was higher than for cardiovascular mortality and cancer.
conclusionWhile liver-related mortality rates decreased significantly among patients with diabetes, NVNA causes made up the majority of cases. Excess mortality for liver-related causes in patients with diabetes compared with controls remained constant in the studied period.
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