Evidence map›Paper›PMID 38506125›Full record

ArticleJournal of neuropathology and experimental neurology2024

Brain banking in the United States and Europe: Importance, challenges, and future trends.

Benjamin Danner, Angelique D Gonzalez, William Cole Corbett, Mohammad Alhneif, Shahroo Etemadmoghadam, Julie Parker-Garza, Margaret E Flanagan

Abstract read
In one paragraph

Article in Journal of neuropathology and experimental neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Brain donation rules in Italy and worldwide: overview of a cutting-edge topic for human brain research.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  12. Bridging minds: Participant perspectives on postmortem brain research and engagement.Neuropathology : official journal of the Japanese Society of Neuropathology · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Benjamin DannerBiggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.
Angelique D GonzalezBiggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.
William Cole CorbettBiggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.
Mohammad AlhneifBiggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.
Shahroo EtemadmoghadamBiggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.
Julie Parker-GarzaBiggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.
Margaret E FlanaganBiggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.ORCID 0009-0008-7078-3545

Funding

South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Claudia Kimie Suemoto · 2021 to 2026
$24.0M
Federated digital pathology platform for AD/ADRD research and diagnosticsU24NS133945 · NINDS · UNIVERSITY OF KENTUCKY · PI BUMGARDNER, CODY, FLANAGAN, MARGARET E · 2023 to 2025
$4.9M
Characterize neuronal and glial cell-specific vulnerability to proteinopathies in Alzheimer's disease using multimodal single-nuclei genomic and epigenomic approachesR01AG082118 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI BONAKDARPOUR, BORNA, CHENG, FEIXIONG · 2023 to 2025
$2.4M
Exploring the origins of myelin abnormalities in normal ageing and in vascular dementiaRF1AG072080 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FLANAGAN, MARGARET E, POPKO, BRIAN J · 2021 to 2021
$2.2M
Exploring the origins of myelin abnormalities in normal ageing and in vascular dementiaR01AG072080 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FLANAGAN, MARGARET E, POPKO, BRIAN J · 2024 to 2025
$1.4M
nvestigating the role of neuroinflammation in Limbic-predominant age related TDP43 encephalopathyK08AG065463 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FLANAGAN, MARGARET E · 2020 to 2024
$816k
NIA NIH HHS K08 AG065463NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG072080NIA NIH HHS R01 AG082118NIA NIH HHS RF1 AG072080NIH HHSNINDS NIH HHS U24 NS133945
6 · The paper itself

Abstract

In recent years, brain banks have become valuable resources for examining the molecular underpinnings of various neurological and psychological disorders including Alzheimer disease and Parkinson disease. However, the availability of brain tissue has significantly declined. Proper collection, preparation, and preservation of postmortem autopsy tissue are essential for optimal downstream brain tissue distribution and experimentation. Collaborations between brain banks through larger networks such as NeuroBioBank with centralized sample request mechanisms promote tissue distribution where brain donations are disproportionately lower. Collaborations between brain banking networks also help to standardize the brain donation and sample preparation processes, ensuring proper distribution and experimentation. Ethical brain donation and thorough processing enhances the responsible conduct of scientific studies. Education and outreach programs that foster collaboration between hospitals, nursing homes, neuropathologists, and other research scientists help to alleviate concerns among potential brain donors. Furthermore, ensuring that biorepositories accurately reflect the true demographics of communities will result in research data that reliably represent populations. Implementing these measures will grant scientists improved access to brain tissue, facilitating a deeper understanding of the neurological diseases that impact millions.

Indexed as

Nervous System DiseasesTissue BanksBrainEuropeHumansTissue DonorsUnited StatesAlzheimer diseaseBrain bankingNeuroBioBankParkinson diseasePostmortem

Identifiers

PMID38506125
PMCPMC10951968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.