Evidence map›Paper›PMID 38505509›Full record

ArticleThe journal of venomous animals and toxins including tropical diseases2024

Cytotoxic effects of crotoxin from

Giovana Pedro, Felipe César da Silva Brasileiro, Jamile Mariano Macedo, Andreimar Martins Soares, Gabriel Caporale Mafra, Carlos Eduardo Fonseca Alves, Renée Laufer-Amorim

Open access · goldAbstract read
In one paragraph

Article in The journal of venomous animals and toxins including tropical diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Genotoxic Activity ofBiology · 2026
    Article
  2. Melittin inhibits proliferation, migration, and invasion in osteosarcoma cell lines using 2D and 3D models.The journal of venomous animals and toxins including tropical diseases · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Giovana PedroSchool of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, SP, Brazil.ORCID 0000-0001-8882-5223
Felipe César da Silva BrasileiroSchool of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, SP, Brazil.
Jamile Mariano MacedoLaboratory of Biotechnology and Education Applied to One Health (LABIOPROT), Oswaldo Cruz Foundation, Fiocruz - Porto Velho, RO, Brazil.
Andreimar Martins SoaresLaboratory of Biotechnology and Education Applied to One Health (LABIOPROT), Oswaldo Cruz Foundation, Fiocruz - Porto Velho, RO, Brazil.
Gabriel Caporale MafraSchool of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, SP, Brazil.
Carlos Eduardo Fonseca AlvesSchool of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, SP, Brazil.ORCID 0000-0002-6702-6139
Renée Laufer-AmorimSchool of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, SP, Brazil.
Department of Physics, Mathematics and Informatics · BYUniversidade Federal de Rondônia · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mammary gland tumors are the most prevalent neoplasm in intact female dogs, and they are good natural models to study comparative oncology. Most canine mammary malignancies, as in women, are commonly refractory to conventional therapies and demand continuous new therapeutic approaches. Methods: In this work, we describe the cytotoxic potential of crotoxin and its subunits compared to doxorubicin (drug of choice) in two canine mammary carcinoma cell lines. Results: Crotoxin, CB-PLA Conclusion: Therefore, this work showed that crotoxin and CB-PLA

Indexed as

Biological compoundsComparative oncologyCrotalus durissus terrificus venomMammary tumor

Identifiers

PMID38505509
PMCPMC10950368
OpenAlexW4392931317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.