Evidence map›Paper›PMID 38505342›Full record

ArticleAngewandte Chemie (Weinheim an der Bergstrasse, Germany)2022

Total Synthesis and Late-Stage C-H Oxidations of

Lukas Anton Wein, Klaus Wurst, Thomas Magauer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Total Synthesis and Late-Stage C-H Oxidations ofAngewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lukas Anton WeinInstitute of Organic Chemistry and Center for Molecular Biosciences Leopold-Franzens-University Innsbruck Innrain 80-82 6020 Innsbruck Austria.
Klaus WurstInstitute of General Inorganic and Theoretical Chemistry Leopold-Franzens-University Innsbruck Innrain 80-82 6020 Innsbruck Austria.ORCID 0000-0002-8774-9051
Thomas MagauerInstitute of Organic Chemistry and Center for Molecular Biosciences Leopold-Franzens-University Innsbruck Innrain 80-82 6020 Innsbruck Austria.ORCID 0000-0003-1290-9556

Funding

Austrian Science Fund FWF P 31023
6 · The paper itself

Abstract

Herein, we present our studies to construct seven ent-trachylobane diterpenoids by employing a bioinspired two-phase synthetic strategy. The first phase provided enantioselective and scalable access to five ent-trachylobanes, of which methyl ent-trachyloban-19-oate was produced on a 300 mg scale. During the second phase, chemical C-H oxidation methods were employed to enable selective conversion to two naturally occurring higher functionalized ent-trachylobanes. The formation of regioisomeric analogs, which are currently inaccessible via enzymatic methods, reveals the potential as well as limitations of established chemical C-H oxidation protocols for complex molecule synthesis.

Indexed as

Biomimetic synthesisC−H activationNatural productsTerpenoidsTotal synthesis

Identifiers

PMID38505342
PMCPMC10947344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.