ArticleAngewandte Chemie (Weinheim an der Bergstrasse, Germany)2021
Using Stereochemistry to Control Mechanical Properties in Thiol-Yne Click-Hydrogels.
Article in Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 1 citations in OpenAlex.
- Using Stereochemistry to Control Mechanical Properties in Thiol-Yne Click-Hydrogels.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021Article
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7 authors at 4 institutions in 1 country.
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Abstract
The stereochemistry of polymers has a profound impact on their mechanical properties. While this has been observed in thermoplastics, studies on how stereochemistry affects the bulk properties of swollen networks, such as hydrogels, are limited. Typically, changing the stiffness of a hydrogel is achieved at the cost of changing another parameter, that in turn affects the physical properties of the material and ultimately influences the cellular response. Herein, we report that by manipulating the stereochemistry of a double bond, formed in situ during gelation, materials with diverse mechanical properties but comparable physical properties can be obtained. Click-hydrogels that possess a high % trans content are stiffer than their high % cis analogues by almost a factor of 3. Human mesenchymal stem cells acted as a substrate stiffness cell reporter demonstrating the potential of these platforms to study mechanotransduction without the influence of other external factors.
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