Evidence map›Paper›PMID 38504970›Full record

ArticleEating behaviors2023

Associations between nutritional intake, stress and hunger biomarkers, and anxiety and depression during the treatment of anorexia nervosa in adolescents and young adults.

Jessica A Lin, Catherine Stamoulis, Amy D DiVasta

Open access · greenAbstract read
In one paragraph

Article in Eating behaviors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jessica A LinDivision of Adolescent and Transition Medicine, Cincinnati Children's Hospital Department of Pediatrics, University of Cincinnati Division of Adolescent and Young Adult Medicine, Boston Children's Hospital.
Catherine StamoulisDivision of Adolescent and Young Adult Medicine, Boston Children's Hospital Department of Pediatrics, Harvard Medical School.
Amy D DiVastaDivision of Adolescent and Young Adult Medicine, Boston Children's Hospital Department of Pediatrics, Harvard Medical School.
Boston Children's Hospital · USHarvard University · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Pediatrician-Scientist Training ProgramT32HD043034 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI FLEISHER, GARY ROBERT · 2003 to 2007
$1.1M
Biomechanical Stimulation & Skeletal Health in Adolescents with Anorexia NervosaK23HD060066 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI DIVASTA, AMY D · 2009 to 2013
$656k
HRSA HHS T71MC00009NCRR NIH HHS UL1 RR025758NICHD NIH HHS K23 HD060066NICHD NIH HHS T32 HD043034
6 · The paper itself

Abstract

Adolescents and young adults (AYA) with anorexia nervosa (AN) frequently have co-occurring anxiety and depression, which can negatively impact prognosis. To inform treatment of co-occurring anxiety and depression, we assessed the association of nutritional intake and hunger/stress hormones on anxiety and depression using a six-month longitudinal study of 50 AYA females receiving care for AN. At baseline and six months, we measured anxiety (Spielberger State/Trait Anxiety Inventory [STAI]), depression (Beck Depression Inventory [BDI]), body mass index (BMI), 3-day dietary intake (total calories and proportion of fat, carbohydrate, protein), and serum cortisol, leptin, and adiponectin. We performed mixed effects linear regression analyses, adjusting for age, duration of AN, and percentage of median BMI (%mBMI). At baseline, median age was 16.3 (interquartile range [IQR]=2.5) years, duration of AN was 6 (IQR=8.8) months and %mBMI was 87.2 (IQR=10.5)%. Fifty-six percent had clinically significant anxiety; 30% had depression. Over 6 months, participants had significant improvements in %mBMI (+2.2[IQR=9.2]%, p<.01), STAI (-9.0[IQR=25.0], p<.01), and BDI (-5.0[IQR=13.8], p<.01) scores. Participants with larger improvements in caloric intake had greater improvements in STAI (p=.03) and BDI scores (p=.04). Larger improvement in BDI was significantly associated with increased fat intake (p<.01), but not carbohydrate or protein intake. Change in STAI was not associated with changes in fat, carbohydrate, or protein intake. Changes in STAI or BDI scores were not associated with changes in cortisol, leptin, or adiponectin. Increased caloric intake may augment treatment of co-occurring anxiety and depression, and increased fat intake may improve depression for AYA with AN.

Indexed as

Anorexia NervosaAdiponectinAdolescentAnxietyBiomarkersCarbohydratesDepressionEatingFemaleHumansHungerHydrocortisoneInfantLeptinLongitudinal StudiesYoung AdultAdiponectinBiomarkersCarbohydratesHydrocortisoneLeptinAdolescentAnorexia NervosaAnxietyDepressionNutrition DisordersYoung Adult

Identifiers

PMID38504970
PMCPMC10948047
OpenAlexW4388194831

What OpenQuestion holds

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LicenceTDM
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.