Evidence map›Paper›PMID 38504937›Full record

ArticleAngewandte Chemie (Weinheim an der Bergstrasse, Germany)2021

Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT).

Thomas Lanyon-Hogg, Markus Ritzefeld, Leran Zhang, Sebastian A Andrei, Balazs Pogranyi, Milon Mondal, Lea Sefer, Callum D Johnston, Claire E Coupland, Jake L Greenfield and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Thomas Lanyon-HoggDepartment of Pharmacology University of Oxford Oxford OX1 3QT UK.ORCID 0000-0002-7092-8096
Markus RitzefeldDepartment of Chemistry Imperial College London London W12 0BZ UK.ORCID 0000-0002-9898-4110
Leran ZhangDepartment of Chemistry Imperial College London London W12 0BZ UK.
Sebastian A AndreiDepartment of Chemistry Imperial College London London W12 0BZ UK.ORCID 0000-0003-2961-8018
Balazs PogranyiDepartment of Chemistry Imperial College London London W12 0BZ UK.ORCID 0000-0002-9269-4462
Milon MondalDepartment of Chemistry Imperial College London London W12 0BZ UK.ORCID 0000-0002-1613-7269
Lea SeferDivision of Structural Biology Wellcome Centre for Human Genetics University of Oxford Oxford OX3 7BN UK.
Callum D JohnstonDepartment of Chemistry Imperial College London London W12 0BZ UK.ORCID 0000-0002-2507-5530
Claire E CouplandDivision of Structural Biology Wellcome Centre for Human Genetics University of Oxford Oxford OX3 7BN UK.
Jake L GreenfieldDepartment of Chemistry Imperial College London London W12 0BZ UK.ORCID 0000-0002-7650-5414
Joshua NewingtonDepartment of Chemistry Imperial College London London W12 0BZ UK.
Matthew J FuchterDepartment of Chemistry Imperial College London London W12 0BZ UK.ORCID 0000-0002-1767-7072
Anthony I MageeNational Heart & Lung Institute Imperial College London London SW7 2AZ UK.
Christian SieboldDivision of Structural Biology Wellcome Centre for Human Genetics University of Oxford Oxford OX3 7BN UK.ORCID 0000-0002-6635-3621
Edward W TateDepartment of Chemistry Imperial College London London W12 0BZ UK.ORCID 0000-0003-2213-5814
Imperial College London · GBCentre for Human Genetics · GBLung Institute · USUniversity of Oxford · GB

Funding

Cancer Research UK 16402Cancer Research UK 20183Cancer Research UK 26752Wellcome Trust
6 · The paper itself

Abstract

The mammalian membrane-bound

Indexed as

enzymesHedgehog acyltransferaseHedgehog signallingmembrane-bound O-acyltransferasephotoaffinity labelling

Identifiers

PMID38504937
PMCPMC10946827
OpenAlexW4205150727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.