ArticlePaediatric & neonatal pain2024
A longitudinal observational study on the epidemiology of painful procedures and sucrose administration in hospitalized preterm neonates.
Article in Paediatric & neonatal pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Effectiveness of the modified Seldinger technique for peripheral central catheter in newborns: a randomized clinical trial.Revista brasileira de enfermagem · 2024Trial
- The effect of open-label placebo on anxiety, cortisol, and pain levels in children with procedural pain.Frontiers in pediatrics · 2026Article
- Nationwide Cross-Sectional Online Survey of Australian Clinicians' Pain Management Practices for Newborns During Heel Lance Procedures.Paediatric & neonatal pain · 2025Article
- Measurement and Sequelae of Neonatal Skin Injuries: A Prospective Diagnostic/Feasibility Study.International wound journal · 2025Article
- Neonatal Sucrose and Internalizing Behaviors at 18 Months in Children Born Very Preterm.JAMA network open · 2025Article
- Neonatal paw pricking alters adolescent behavior in a sex-dependent manner and sucrose partially remediates the effects.Physiology & behavior · 2024Article
- Increasing the Use of Newborn Pain Treatment Following the Implementation of a Parent-Targeted Video: An Outcome Evaluation.Children (Basel, Switzerland) · 2024Article
- Cumulative sucrose exposure for repeated procedural pain in preterm neonates and neurodevelopment at 18 months of corrected age: a prospective observational longitudinal study.BMJ paediatrics open · 2024Observational
- A longitudinal observational study on the epidemiology of painful procedures and sucrose administration in hospitalized preterm neonates.Paediatric & neonatal pain · 2024Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although sucrose is widely administered to hospitalized infants for single painful procedures, total sucrose volume during the entire neonatal intensive care unit (NICU) stay and associated adverse events are unknown. In a longitudinal observation study, we aimed to quantify and contextualize sucrose administration during the NICU stay. Specifically, we investigated the frequency, nature, and severity of painful procedures; proportion of procedures where neonates received sucrose; total volume of sucrose administered for painful procedures; and incidence and type of adverse events. Neonates <32 weeks gestational age at birth and <10 days of life were recruited from four Canadian tertiary NICUs. Daily chart reviews of documented painful procedures, sucrose administration, and any associated adverse events were undertaken. One hundred sixty-eight neonates underwent a total of 9093 skin-breaking procedures (mean 54.1 [±65.2] procedures/neonate or 1.1 [±0.9] procedures/day/neonate) during an average NICU stay of 45.9 (±31.4) days. Pain severity was recorded for 5399/9093 (59.4%) of the painful procedures; the majority (5051 [93.5%]) were heel lances of moderate pain intensity. Sucrose was administered for 7839/9093 (86.2%) of painful procedures. The total average sucrose volume was 5.5 (±5.4) mL/neonate or 0.11 (±0.08) mL/neonate/day. Infants experienced an average of 7.9 (±12.7) minor adverse events associated with pain and/or sucrose administration that resolved without intervention. The total number of painful procedures, sucrose volume, and incidence of adverse events throughout the NICU stay were described addressing an important knowledge gap in neonatal pain. These data provide a baseline for examining the association between total sucrose volume during NICU stay and research on longer-term behavioral and neurodevelopmental outcomes.
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