ArticleNigerian medical journal : journal of the Nigeria Medical Association
Relationship of Vitamin D Status with Thyroid Autoimmunity in New Onset Autoimmune Hypothyroidism.
Article in Nigerian medical journal : journal of the Nigeria Medical Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Study of serum vitamin D level in new onset hypothyroid patients and its correlation with thyroid related parameters and antibody titers. Objectives: We aimed to compare serum vitamin D level in new onset hypothyroid patients versus controls. Furthermore we evaluated for any association of vitamin D status with hypothyroid state and its correlation with various thyroid related parameters. Methodology: In this cross sectional study , 61 new onset hypothyroid subjects (cases) and 40 age, sex and BMI matched healthy individuals (controls) were recruited. Measurements of serum vitamin D, thyroid hormones, thyroid peroxidase antibody (TPO-Ab), parathyroid hormone (PTH), calcium and phosphorus were done for all study participants. Results: The mean serum vitamin D in cases (22.95±8.59 ng/ml) was significantly lower than the controls (27.9±7.85 ng/ml) (p<0.01). The prevalence of vitamin D deficiency was significantly higher among hypothyroid subjects than controls (p=0.009). Hypothyroid subjects with vitamin D deficiency group had significantly higher TSH level, greater thyroid volume and elevated anti TPO titres than those with vitamin D sufficiency. Serum vitamin D level had significant inverse correlation with anti TPO-Abtiters even after adjustment for age, sex and BMI. Conclusion: Serum vitamin D is significantly low in new onset hypothyroid patients than healthy controls. Hypothyroid patients with vitamin D deficiency have significantly higher TSH, antibody titres and thyroid volume. A significant negative correlation was observed between serum vitamin D leveland anti TPO titres. Moreover, serum vitamin D remained an independent predictor of TPO level among hypothyroid subjects.
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38504787PMC10903289W4394766395What OpenQuestion holds
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