Evidence map›Paper›PMID 38504632›Full record

SynthesisEuropean journal of neurology2024

Reduction in short interval intracortical inhibition from the early stage reflects the pathophysiology in amyotrophic lateral sclerosis: A meta-analysis study.

Mana Higashihara, Nathan Pavey, Parvathi Menon, Mehdi van den Bos, Kazumoto Shibuya, Satoshi Kuwabara, Matthew C Kiernan, Masayoshi Koinuma, Steve Vucic

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Mana HigashiharaDepartment of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.ORCID 0000-0001-8015-2028
Nathan PaveyBrain and Nerve Research Center, University of Sydney, Sydney, New South Wales, Australia.
Parvathi MenonBrain and Nerve Research Center, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-6935-5852
Mehdi van den BosBrain and Nerve Research Center, University of Sydney, Sydney, New South Wales, Australia.
Kazumoto ShibuyaNeurology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0003-4061-0412
Satoshi KuwabaraNeurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Matthew C KiernanNeuroscience Resarch Australia, University of New South Wales, Sydney, New South Wales, Australia.
Masayoshi KoinumaFaculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.
Steve VucicBrain and Nerve Research Center, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-8323-873X
The University of Sydney · AUChiba University · JPRoyal Prince Alfred Hospital · AUTeikyo Heisei University · JPTokyo Metropolitan Institute of Gerontology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCortical hyperexcitability has been identified as a diagnostic and pathogenic biomarker of amyotrophic lateral sclerosis (ALS). Cortical excitability is assessed by transcranial magnetic stimulation (TMS), a non-invasive neurophysiological technique. The TMS biomarkers exhibiting highest sensitivity for cortical hyperexcitability in ALS remain to be elucidated. A meta-analysis was performed to determine the TMS biomarkers exhibiting the highest sensitivity for cortical hyperexcitability in ALS.

methodsA systematic literature review was conducted of all relevant studies published in the English language by searching PubMed, MEDLINE, Embase and Scopus electronic databases from 1 January 2006 to 28 February 2023. Inclusion criteria included studies reporting the utility of threshold tracking TMS (serial ascending method) in ALS and controls.

resultsIn total, more than 2500 participants, incorporating 1530 ALS patients and 1102 controls (healthy, 907; neuromuscular, 195) were assessed with threshold tracking TMS across 25 studies. Significant reduction of mean short interval intracortical inhibition (interstimulus interval 1-7 ms) exhibited the highest standardized mean difference with moderate heterogeneity (-0.994, 95% confidence interval -1.12 to -0.873, p < 0.001; Q = 38.61, p < 0.05; I

conclusionThis large meta-analysis study disclosed that mean short interval intracortical inhibition reduction exhibited the highest sensitivity for cortical hyperexcitability in ALS. Combined findings from this meta-analysis suggest that research strategies aimed at understanding the cause of inhibitory interneuronal circuit dysfunction could enhance understanding of ALS pathogenesis.

Indexed as

Amyotrophic Lateral SclerosisMotor CortexNeural InhibitionTranscranial Magnetic StimulationEvoked Potentials, MotorHumansamyotrophic lateral sclerosiscortical hyperexcitabilitymotor neuron diseaseSICIthreshold tracking TMS

Identifiers

PMID38504632
PMCPMC11235657
OpenAlexW4393008969

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.