Evidence map›Paper›PMID 38504543›Full record

Trial reportJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2024

Effectiveness and safety of Jiawei Xiaoyao pill in the treatment of premenstrual syndrome (liver depression, spleen deficiency, and blood-heat syndrome): a multi-center, randomized, placebo-controlled trial.

L I Xiyu, Yang Yanhong, Sun Jian, Nie Quanfang, Liu Lifen, L I Guifen, Y U Junping, Zhang Zhuangjin, X U Yi, Zou Ting and 1 more

Open access · greenAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Mechanisms of Baishao () and Gancao () on major depressive disorder: network pharmacology and o validation.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025
    Article
  5. Study on subtyping and Traditional Chinese Medicine treatment of depression based on machine learning and text mining.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

L I XiyuDepartment of Gynecology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
Yang YanhongDepartment of Gynecology, Luoyang 1st Hospital of TCM, Luoyang 471099, China.
Sun JianDepartment of Gynecology, Zaozhuang Hospital of TCM, Zaozhuang 277099, China.
Nie QuanfangDepartment of Gynecology and Obstetrics, Loudi Central Hospital, Loudi 417099, China.
Liu LifenDepartment of Gynecology and Obstetrics, Yiyang 1st Hospital of TCM, Yiyang 413002, China.
L I GuifenDepartment of Gynecology, Harrison International Peace Hospital, Hengshui 053000, China.
Y U JunpingDepartment of Gynecology and Obstetrics, Shanxi Fenyang Hospital, Fenyang 032299, China.
Zhang ZhuangjinDepartment of Gynecology and Obstetrics, Hengyang Chinese Medicine Hospital, Hengyang 421001, China.
X U YiScientific Research Institute of Beijing Tongrentang Technology Development Co., Ltd. Beijing 100061, China.
Zou Ting10 Female Reproductive and Health Medicine Research Committee of Chinese Traditional Medicine Association, Beijing 100061, China.
Shi YunDepartment of Gynecology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine · CNChinese Preventive Medicine Association · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effectiveness and safety of Jiawei Xiaoyao pill (，JXP) in the treatment of symptoms associated with premenstrual syndrome (PMS).

methodsA total of 144 regularly menstruating women with PMS were recruited at 8 sites in China from August 2017 to December 2018, and randomized to receive either a JXP or a matching placebo (12 g/d, 6 g twice a day) for 3 menstrual cycles. The primary indicator was the reduced Daily Record of Severity of Problems (DRSP) scores in the luteal phase after 3 months of treatment. The safety outcomes included clinical adverse events (AEs), adverse reactions (ARs), changes in vital signs, and laboratory tests.

resultsJXP surpassed the placebo in reducing DRSP scores (psychological/somatic dysfunction) in the luteal phase over 3 menstrual cycles of treatment (PFAS = 0.002, PPPS = 0.001). Additionally, there were no significant differences in the incidence of AEs, severe AEs, withdrawal due to AEs and ARs between the two groups (all

conclusionsJXP was superior to the placebo in relieving the symptoms associated with PMS, which signified that JXP may be effective, safe, and well-tolerated as an alternative therapy.

Indexed as

Drugs, Chinese HerbalPremenstrual SyndromeSpleenDepressionDouble-Blind MethodFemaleHot TemperatureHumansLiverDrugs, Chinese Herbalxiaoyaodouble-blind methodJiawei Xiaoyao pillpremenstrual syndromerandomized controlled trial

Identifiers

PMID38504543
PMCPMC10927397
OpenAlexW4394761845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.