Trial reportAging cell2024
Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis.
Open access · goldAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
10.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Effects of time-restricted eating without caloric restriction on blood pressure and cardiometabolic profile in non-diabetic adults: a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2025Pooled it
- Beneficial Effects of a Moderately High-Protein Diet on Telomere Length in Subjects with Overweight or Obesity.Nutrients · 2025Trial
- Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis.Aging cell · 2024Trial
- Effect ofVeterinary and animal science · 2026Article
- Quadriceps mitochondrial DNA quantity, quality, and gene expression after 2 years of calorie restriction: exploratory results from the CALERIE trial.GeroScience · 2026Article
- CardioMetAge estimates cardiometabolic aging and predicts disease outcomes.BMC medicine · 2026Article
- Biological Mechanisms of Strength Preservation During Calorie Restriction-Induced Weight Loss Among Young- to Middle-Aged Adults without Obesity.bioRxiv : the preprint server for biology · 2026Article
- Longevity, Centenarians, and Lifestyle: Any ''Tips'' to Live Longer?Current nutrition reports · 2026Review
- Aging Reduces Intestinal Stem Cell Activity in Killifish and Intermittent Fasting Reverses Intestinal Gene Expression Patterns.Aging cell · 2025Article
- Dietary and Pharmacological Modulation of Aging-Related Metabolic Pathways: Molecular Insights, Clinical Evidence, and a Translational Model.International journal of molecular sciences · 2025Review
- DNA methylation-based health predictors: advances, applications, and perspectives.Epigenomics · 2025Review
- Epigenetic Regulation of Aging and its Rejuvenation.MedComm · 2025Review
- Western Diet and Cognitive Decline: A Hungarian Perspective-Implications for the Design of the Semmelweis Study.Nutrients · 2025Review
- From telomeres and senescence to integrated longevity medicine: redefining the path to extended healthspan.Biogerontology · 2025Review
- Review
- The association of visceral and subcutaneous fat areas with phenotypic age in non-elderly adults, mediated by HOMA-IR and HDL-C.Lipids in health and disease · 2025Article
- Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone?Antioxidants (Basel, Switzerland) · 2025Review
- Cognitive dysfunction-an under looked avenue to promote health in incarcerated elderly population through yoga.Frontiers in human neuroscience · 2025Article
- Epigenetic modulation by life-style: advances in diet, exercise, and mindfulness for disease prevention and health optimization.Frontiers in nutrition · 2025Review
- The Impact of Aging on Neurological Diseases in the Elderly: Molecular Mechanisms and Therapeutic Perspectives.Aging and disease · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 8 institutions in 3 countries.
Waylon J HastingsDepartment of Psychiatry and Behavioral Sciences, Tulane University School of Medicine, New Orleans, Louisiana, USA.ORCID 0000-0003-0875-2568
Qiaofeng YeDepartment of Biobehavioral Health, Pennsylvania State University, University Park, State College, Pennsylvania, USA.
Sarah E WolfDepartment of Biobehavioral Health, Pennsylvania State University, University Park, State College, Pennsylvania, USA.
Calen P RyanButler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, New York, USA.
Sai Krupa DasJean Mayer, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.ORCID 0000-0003-0788-0461
Kim M HuffmanDuke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Michael S KoborEdwin S.H. Leong Centre for Healthy Aging, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
William E KrausDuke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Julia L MacIsaacEdwin S.H. Leong Centre for Healthy Aging, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
Corby K MartinPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Susan B RacetteCollege of Health Solutions, Arizona State University, Phoenix, Arizona, USA.ORCID 0000-0002-6932-1887
Leanne M RedmanPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Daniel W BelskyButler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, New York, USA.ORCID 0000-0001-5463-2212
Idan ShalevDepartment of Biobehavioral Health, Pennsylvania State University, University Park, State College, Pennsylvania, USA.ORCID 0000-0003-0773-4835
Pennsylvania State University · USColumbia University · USDuke University · USPennington Biomedical Research Center · USUniversity of British Columbia · CAArizona State University · USTufts University · USTulane University · US
Funding
Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1MResearch BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5MCoordinating Center for CALERIEU01AG022132 · NIA · DUKE UNIVERSITY · PI KRAUS, WILLIAM E · 2002 to 2013
$24.9MMetabolic Adaptations to Two Year Caloric RestrictionU01AG020478 · NIA · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RAVUSSIN, ERIC · 2002 to 2008
$13.4MCaloric Restriction and Aging in HumansU01AG020487 · NIA · WASHINGTON UNIVERSITY · PI HOLLOSZY, JOHN O. · 2001 to 2009
$8.9MDietary Energy Restriction and Metabolic Aging in HumansU01AG020480 · NIA · TUFTS UNIVERSITY BOSTON · PI ROBERTS, SUSAN B · 2002 to 2008
$8.2MLegacy Effects of CALERIE, a 2-year Calorie Restriction Intervention, on Hallmarks of Healthspan and AgingR01AG071717 · NIA · TUFTS UNIVERSITY BOSTON · PI Sai Krupa Das, Susan Beth Racette · 2021 to 2026
$6.3MENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGYR33AG070455 · NIA · DUKE UNIVERSITY · PI KIM M. HUFFMAN, WILLIAM E KRAUS · 2021 to 2026
$4.0MPsychosocial Determinants and Biological Pathway to Healthy Aging (Pathways)T32AG049676 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI LYNN M. MARTIRE · 2016 to 2026
$3.9MDIAL Health SupplementU01AG073204 · NIA · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MARTIN, CORBY K, REDMAN, LEANNE MAREE · 2021 to 2024
$3.7MBiomarkers of Caloric Restriction in Humans: the CALERIE BiorepositoryU24AG047121 · NIA · DUKE UNIVERSITY · PI KRAUS, WILLIAM E, PIEPER, CARL F · 2015 to 2019
$3.2MElucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research NetworkU24AG066528 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI DRURY, STACY SCHMIDT · 2019 to 2023
$3.0MNIA NIH HHS R01 AG061378NIA NIH HHS R01 AG071717NIA NIH HHS R03 AG071549NIA NIH HHS R33 AG070455NIA NIH HHS T32 AG049676NIA NIH HHS U01 AG020478NIA NIH HHS U01 AG020480NIA NIH HHS U01 AG020487NIA NIH HHS U01 AG022132NIA NIH HHS U01 AG073204NIA NIH HHS U24 AG047121NIA NIH HHS U24 AG066528NIDDK NIH HHS P30 DK072476NIEHS NIH HHS U01 ES030949NIGMS NIH HHS U54 GM104940
Abstract
Caloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ randomized healthy, nonobese men and premenopausal women (age 21-50y; BMI 22.0-27.9 kg/m
Indexed as
Caloric RestrictionTelomereAdultAgingDNA MethylationFemaleHumansMaleMiddle AgedTelomere HomeostasisYoung Adultcaloric restrictiongerosciencerandomized clinical trialtelomere length
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.