ArticleNature metabolism2024
Trigonelline is an NAD
Open access · hybridAbstract read
In one paragraph
Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
37.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Stable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes.Life metabolism · 2026Review
- Review
- Developing Metal-Polyphenol Network-Based Single-Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Strengthening muscle for healthy ageing: innovative treatments for sarcopenia.Nature reviews. Drug discovery · 2026Review
- Redox coupling of lactate and β-hydroxybutyrate: An inter-organ circuit linking metabolic flexibility, mitochondrial adaptation, and disease.Redox biology · 2026Review
- Machine Learning-Derived Sarcopenia Signature Identifies High-Risk Molecular State in T2D Skeletal Muscle.Cell biochemistry and biophysics · 2026Article
- Comprehensive transcriptomic profiling reveals impaired polyamine metabolism as a contributor to age-related muscle decline.iScience · 2026Article
- Identification of Isoliensinine as a Novel CCR5 Inhibitor for the Prevention of Skeletal Muscle Atrophy Through Virtual Screening and Experimental Validation.Molecules (Basel, Switzerland) · 2026Article
- An Intelligent Identification Method for the Processing Degree of Stir-FriedFoods (Basel, Switzerland) · 2026Article
- A Purified Lycii Fructus Polysaccharide Fraction Extends Healthspan inAntioxidants (Basel, Switzerland) · 2026Article
- Coffee as a polypharmacological modulator of mitochondrial health: from molecular mechanisms to translational implications.Journal of translational medicine · 2026Review
- Astrocytic Redox Homeostasis as a Metabolic Modulator of DNA Damage and Repair in the Ischemic Penumbra.Cells · 2026Review
- Metabolically engineered probiotic OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy.Cell reports. Medicine · 2026Article
- Metabolomic Signatures of Commercial Ready-to-Drink Beverages by Dual-Mode Untargeted LC-MS/MS.Metabolites · 2026Article
- Phytochemical-Based Therapeutic Strategies for Sarcopenia: From Molecular Mechanisms to Clinical Translation.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Targeting Mitochondria in Aging-Related Diseases: Therapeutic Potential and Obstacles.MedComm · 2026Review
- NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration.Aging cell · 2026 · on this mapArticle
- Vitamin B3 suppressesTranslational cancer research · 2026Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 11 institutions in 9 countries.
Mathieu MembrezNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-2771-4452
Eugenia MigliavaccaNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-1883-1972
Stefan ChristenNestlé Institute of Food Safety and Analytical Sciences, Nestlé Research, Lausanne, Switzerland.
Keisuke YakuDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, Toyama, Japan.ORCID http://orcid.org/0000-0002-2420-4265
Jennifer TrieuCentre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-0016-0998
Alaina K LeeCentre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.
Francesco MorandiniNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Maria Pilar GinerNestlé Institute of Food Safety and Analytical Sciences, Nestlé Research, Lausanne, Switzerland.
Jade StinerNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Mikhail V MakarovMitchell Cancer Institute, Department of Pharmacology, F. P. Whiddon College of Medicine, University of South Alabama, Mobile, AL, USA.
Emma S GarrattInstitute of Developmental Sciences, Human Developmental and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
Maria F VasiloglouNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-2013-2858
Lucie ChanvillardNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Emilie DalbramNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7679-5896
Amy M EhrlichNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
José Luis Sanchez-GarciaNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Carles CantoNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-5167-7922
Leonidas G KaragounisNestlé Health Science, Translation Research, Lausanne, Switzerland.
Jonas T TreebakNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1488-7012
Marie E MigaudMitchell Cancer Institute, Department of Pharmacology, F. P. Whiddon College of Medicine, University of South Alabama, Mobile, AL, USA.ORCID http://orcid.org/0000-0002-9626-2405
Ramin HeshmatChronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Farideh RaziMetabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Science Institute, Tehran University of Medical Sciences, Tehran, Iran.
Neerja KarnaniSingapore Institute for Clinical Sciences (A*STAR), Singapore, Singapore.
Afshin OstovarOsteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Farshad FarzadfarNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Stacey K H TayKTP-National University Children's Medical Institute, National University Hospital, Singapore, Singapore.ORCID http://orcid.org/0000-0002-3077-4184
Matthew J SandersNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Karen A LillycropInstitute of Developmental Sciences, Human Developmental and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
Keith M GodfreyInstitute of Developmental Sciences, Human Developmental and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0002-4643-0618
Takashi NakagawaDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, Toyama, Japan.ORCID http://orcid.org/0000-0001-5539-7605
Sofia MocoNestlé Institute of Food Safety and Analytical Sciences, Nestlé Research, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-8170-8876
René KoopmanCentre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.
Gordon S LynchCentre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-9220-9810
Vincenzo SorrentinoNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland. vsorrent@nus.edu.sg.ORCID http://orcid.org/0000-0002-7212-370X
Jerome N FeigeNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland. Jerome.feige@rd.nestle.com.ORCID http://orcid.org/0000-0002-4751-264X
Nestlé (Switzerland) · CHTehran University of Medical Sciences · IRThe University of Melbourne · AUUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Copenhagen · DKUniversity of Toyama · JPUSA Mitchell Cancer Institute · USAgency for Science, Technology and Research · SGNational University Hospital · SGNational University of Singapore · SGUniversity of Bern · CH
Funding
Interdisciplinary Research Network on Early Adversity & Later Life ReversibilityU24AG047867 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GODFREY, KEITH, MCEWEN, BRUCE S. · 2014 to 2018
$954kB-vitamins and NAD mechanism, or when vitamin B3's bioavailability is not enough.R21AT009908 · NCCIH · UNIVERSITY OF SOUTH ALABAMA · PI MIGAUD, MARIE EUGENIE · 2018 to 2019
$423kNCCIH NIH HHS R21 AT009908NIA NIH HHS U24 AG047867
Abstract
Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD
Indexed as
AlkaloidsSarcopeniaAgingAnimalsCaenorhabditis elegansHumansMaleMiceMuscle, SkeletalNADAlkaloidsNADtrigonelline
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.